about
P688
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophyThe arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca(2+) release due to an impaired ability to buffer store Ca(2+)The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failureDefective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunctionThe inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptorHypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell lineRyanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytesRyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic isletsPhosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmiasFKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac deathAnalysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in miceThree-dimensional reconstruction of the recombinant type 2 ryanodine receptor and localization of its divergent region 1The predicted TM10 transmembrane sequence of the cardiac Ca2+ release channel (ryanodine receptor) is crucial for channel activation and gatingEarly cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel.Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusionPresenilin 2 regulates the systolic function of heart by modulating Ca2+ signalingAblation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmiasRole of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunctionDirect association of the reticulon protein RTN1A with the ryanodine receptor 2 in neuronsEmbryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2.RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin miceThe ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during developmentDynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptorPhospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophyMolecular identification of the ryanodine receptor pore-forming segmentFKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cellsArrhythmogenic mechanisms in a mouse model of catecholaminergic polymorphic ventricular tachycardia.Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failureAnnotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics.
P921
Q24295360-63853EC5-61B1-4588-BE1A-E12EF8C61107Q24297159-54FF2FD3-B816-4A67-AA89-383E52FC34DDQ24299296-EAD0323F-A7DA-44DF-AE06-B9A305A54EA4Q24302344-019C7354-D273-4C6D-A5B4-B30723D530E6Q24307307-EE4F9A9B-BD06-4D00-A50C-B9A216452329Q24313138-B30EC287-55AE-406A-A006-D09A70B9C1B5Q24315860-E4EA1468-60BC-4F21-BC90-7DADC2C690A4Q24320352-DB74C8F6-B7B8-41C7-8C52-25C61E12BAF6Q24337832-A3039DCF-B9EC-4F3E-8756-5EFFC01D2654Q28183817-97FC1BF7-F48F-48E8-BE3C-550193499B76Q28504805-1A0FEB60-44F9-4764-A708-278F2B3335BAQ28505252-D9FF2162-3F96-4AC4-A9CF-19B02464EA6AQ28505435-F4BFA735-09BD-4316-AF70-BD442B0D6FBDQ28506475-667F9A53-6EF7-4EA9-9535-EDA795AD03BCQ28508488-B9DBF588-AE4B-45C8-93A6-3DC145A47C05Q28509444-C37E5E17-4C32-45A7-8C20-6E9986D8532DQ28511129-B8EB2213-D9CE-44B2-9392-B425FA2A4674Q28511926-85EF3778-B697-49C4-819E-81A367D729BDQ28565048-EF584B72-6409-4CBE-9A98-56539A7B3846Q28584945-B8AC69FA-C5B1-432F-BBDF-6FE5A79533F2Q28585005-4B2D4B61-B5D4-4AC9-8D8E-70238EF4B5FFQ28587739-B5CAC00A-E21F-441F-91E5-DF659B6CF8CBQ28589538-328F26EC-BF9D-4F18-9875-D329D5015D06Q28591518-1DD9095F-03EE-4C70-A7B9-CD7198C85D5AQ28592671-D60510B9-8157-403D-B5A4-E5E22EF99602Q28593597-6904CB5B-278E-4F78-B7FD-565692C51633Q28595062-91053731-FA13-4483-AB16-340B68817F9EQ30495045-A7255815-4220-4402-B48F-46B1921C9EBBQ33983329-3AA8757F-8561-433A-8FC7-D24B4A0A242B
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
proteinë
@sq
proteïne in Ryanodine receptor 2, cardiac
@nl
protèin
@ace
بروتين في فأر المنازل
@ar
name
Ryanodine receptor 2, cardiac
@en
Ryanodine receptor 2, cardiac
@nl
type
label
Ryanodine receptor 2, cardiac
@en
Ryanodine receptor 2, cardiac
@nl
altLabel
Ryr2
@en
calcium release channel
@en
cardiac muscle ryanodine receptor
@en
cardiac muscle ryanodine receptor-calcium release channel
@en
ryanodine receptor 2
@en
ryanodine receptor type 2
@en
type 2 ryanodine receptor
@en
prefLabel
Ryanodine receptor 2, cardiac
@en
Ryanodine receptor 2, cardiac
@nl
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XP_006516673
XP_011242598
XP_017170934
XP_017170935
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XP_017170937
XP_017170938
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ENSMUSP00000021750
ENSMUSP00000127991
ENSMUSP00000152051
ENSMUSP00000152510
ENSMUSP00000152669