Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization
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EGFR C797S mutation mediates resistance to third-generation inhibitors in T790M-positive non-small cell lung cancerFrom systems to structure: bridging networks and mechanismEGF receptor trafficking: consequences for signaling and cancerMolecular mechanisms of disease-causing missense mutationsEnhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancerCoarse-grained molecular simulation of epidermal growth factor receptor protein tyrosine kinase multi-site self-phosphorylationSingle Particle Tracking Reveals that EGFR Signaling Activity Is Amplified in Clathrin-Coated PitsCracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function MutationsMechanism for activation of mutated epidermal growth factor receptors in lung cancerAn ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 PseudokinaseCrystal structure of a BRAF kinase domain monomer explains basis for allosteric regulationHotspot mutations in KIT receptor differentially modulate its allosterically coupled conformational dynamics: impact on activation and drug sensitivityThe SH2 domain regulates c-Abl kinase activation by a cyclin-like mechanism and remodulation of the hinge motionTowards a Molecular Understanding of the Link between Imatinib Resistance and Kinase Conformational DynamicsHydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib.Structure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.Targeting electrostatic interactions in accelerated molecular dynamics with application to protein partial unfolding.Non-degradative Ubiquitination of Protein Kinases.Exploring Molecular Mechanisms of Paradoxical Activation in the BRAF Kinase Dimers: Atomistic Simulations of Conformational Dynamics and Modeling of Allosteric Communication Networks and Signaling Pathways.OpenStructure: an integrated software framework for computational structural biologyConformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.Phase I dose-escalation study of 5-day intermittent oral lapatinib therapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer.Dynamic, structural and thermodynamic basis of insulin-like growth factor 1 kinase allostery mediated by activation loop phosphorylation.A highly efficient peptide substrate for EGFR activates the kinase by inducing aggregationEpidermal Growth Factor Receptor Cell Proliferation Signaling PathwaysComputational and Experimental Characterization of Patient Derived Mutations Reveal an Unusual Mode of Regulatory Spine Assembly and Drug Sensitivity in EGFR Kinase.Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesConformational Transition Pathways of Epidermal Growth Factor Receptor Kinase Domain from Multiple Molecular Dynamics Simulations and Bayesian Clustering.A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinaseThe structural basis for cancer treatment decisions.Dynamic architecture of a protein kinase.The influence of adnectin binding on the extracellular domain of epidermal growth factor receptor.The Arabidopsis thaliana SERK1 kinase domain spontaneously refolds to an active state in vitro.Ligand binding and dynamics of the monomeric epidermal growth factor receptor ectodomain.Applications of hydrogen/deuterium exchange MS from 2012 to 2014.Unique molecular landscapes in cancer: implications for individualized, curated drug combinations.A phenylalanine rotameric switch for signal-state control in bacterial chemoreceptors.Conformational changes in talin on binding to anionic phospholipid membranes facilitate signaling by integrin transmembrane helicesA coarse-grained elastic network atom contact model and its use in the simulation of protein dynamics and the prediction of the effect of mutationsSrc mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells
P2860
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P2860
Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization
description
2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
name
Oncogenic mutations counteract ...... promote receptor dimerization
@ast
Oncogenic mutations counteract ...... promote receptor dimerization
@en
Oncogenic mutations counteract ...... promote receptor dimerization
@en-gb
Oncogenic mutations counteract ...... promote receptor dimerization
@nl
type
label
Oncogenic mutations counteract ...... promote receptor dimerization
@ast
Oncogenic mutations counteract ...... promote receptor dimerization
@en
Oncogenic mutations counteract ...... promote receptor dimerization
@en-gb
Oncogenic mutations counteract ...... promote receptor dimerization
@nl
prefLabel
Oncogenic mutations counteract ...... promote receptor dimerization
@ast
Oncogenic mutations counteract ...... promote receptor dimerization
@en
Oncogenic mutations counteract ...... promote receptor dimerization
@en-gb
Oncogenic mutations counteract ...... promote receptor dimerization
@nl
P2093
P3181
P1433
P1476
Oncogenic mutations counteract ...... promote receptor dimerization
@en
P2093
Anton Arkhipov
David E Shaw
Eric T Kim
John Jumper
Michael P Eastwood
Ron O Dror
Xuewu Zhang
Yibing Shan
P304
P356
10.1016/J.CELL.2012.02.063
P407
P50
P577
2012-05-11T00:00:00Z