An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase
about
The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent mannerPseudokinases: update on their functions and evaluation as new drug targets.Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-bindingPharmacological targeting of the pseudokinase Her3ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activationTargeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum.Navigating into the binding pockets of the HER family protein kinases: discovery of novel EGFR inhibitor as antitumor agent.Effective treatment of HER2-amplified breast cancer by targeting HER3 and β1 integrinFlicking the molecular switch underlying MLKL-mediated necroptosis.Going for broke: targeting the human cancer pseudokinome.A tale of two domains - a structural perspective of the pseudokinase, MLKL.Nucleotide-binding mechanisms in pseudokinases.Characterization of Ligand Binding to Pseudokinases Using a Thermal Shift Assay.The SH2 domain of Abl kinases regulates kinase autophosphorylation by controlling activation loop accessibility.
P2860
Q28834261-C73A9138-57FA-444F-933D-809D28016685Q30397636-C2F0EDA6-8442-45BF-B6CB-FC20E766522EQ33627422-B3812591-31B6-4CDD-ADDD-6E93A4061044Q34514043-0011FC04-31D2-47CD-AE33-125616FD7B99Q35484880-43771B36-D7E0-4F9D-AD6B-B0935AD3B9B7Q35890128-8CF63196-B8D4-4BF0-A310-1F600655FCC6Q35896406-C338347F-1097-47E6-855A-3AD8F10AA0B4Q36619622-84E7862C-763C-42DE-BFBC-8E6B2B2E65F4Q36997901-1B01CB16-46AB-4935-BB8D-46254C74B0D4Q38307398-553E7FA2-BC49-43F8-8027-EF741DE2D203Q38580336-3557BF26-2E16-471C-A477-A4FFE7D3C211Q38641286-304480CA-3DAB-4552-8DD9-B46349309389Q50878637-42714632-6929-485D-9DF6-3701F10424CFQ52655033-B0D79FAD-E1BC-4119-8F72-C3EEB09EB906
P2860
An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase
description
2014 nî lūn-bûn
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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2014 թվականի ապրիլին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase
@ast
An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase
@en
An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase
@nl
type
label
An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase
@ast
An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase
@en
An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase
@nl
prefLabel
An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase
@ast
An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase
@en
An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase
@nl
P2093
P2860
P921
P1476
An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase
@en
P2093
Mark M Moasser
Natalia Jura
Peter Littlefield
P2860
P356
10.1016/J.CHEMBIOL.2014.02.011
P577
2014-04-24T00:00:00Z