The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors - Wikidata - wikimedia - TriplyDB

The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors

The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors

http://www.wikidata.org/entity/Q24321690

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Intrinsically unstructured domain 3 of hepatitis C Virus NS5A forms a "fuzzy complex" with VAPB-MSP domain which carries ALS-causing mutations The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendrites VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis Human VAP-C negatively regulates hepatitis C virus propagation Sperm and oocyte communication mechanisms controlling C. elegans fertility Regulated trafficking of the MSP/Eph receptor during oocyte meiotic maturation in C. elegans The Unfolded Protein Response and the Role of Protein Disulfide Isomerase in Neurodegeneration Autophagy and Neurodegeneration: Insights from a Cultured Cell Model of ALS Molecular motor proteins and amyotrophic lateral sclerosis Eph receptor signaling in C. elegans Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis Drosophila as a model for unfolded protein response research Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS Redox regulation in amyotrophic lateral sclerosis ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation Amyotrophic lateral sclerosis-linked mutant VAPB inclusions do not interfere with protein degradation pathways or intracellular transport in a cultured cell model Emerging mechanisms of molecular pathology in ALS Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport.Structural, stability, dynamic and binding properties of the ALS-causing T46I mutant of the hVAPB MSP domain as revealed by NMR and MD simulations Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans C-Terminal Auto-Regulatory Motif of Hepatitis C Virus NS5B Interacts with Human VAPB-MSP to Form a Dynamic Replication Complex Bacteria, yeast, worms, and flies: exploiting simple model organisms to investigate human mitochondrial diseases VAPC, an human endogenous inhibitor for hepatitis C virus (HCV) infection, is intrinsically unstructured but forms a "fuzzy complex" with HCV NS5B.The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control Modelling amyotrophic lateral sclerosis: progress and possibilities MSP hormonal control of the oocyte MAP kinase cascade and reactive oxygen species signaling.The secreted MSP domain of C. elegans VAPB homolog VPR-1 patterns the adult striated muscle mitochondrial reticulum via SMN-1 The C. elegans VAPB homolog VPR-1 is a permissive signal for gonad development.Shared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseases Eph receptors and ephrins in cancer: bidirectional signalling and beyond.Drosophila melanogaster in the study of human neurodegeneration.Neurodegenerative models in Drosophila: polyglutamine disorders, Parkinson disease, and amyotrophic lateral sclerosis.Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics Resolving the paradox for protein aggregation diseases: NMR structure and dynamics of the membrane-embedded P56S-MSP causing ALS imply a common mechanism for aggregation-prone proteins to attack membranes Genetic heterogeneity of amyotrophic lateral sclerosis: implications for clinical practice and research.VAMP-associated protein B (VAPB) promotes breast tumor growth by modulation of Akt activity.A genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis.Flightless flies: Drosophila models of neuromuscular disease.Mechanisms of neuroprotection by protein disulphide isomerase in amyotrophic lateral sclerosis.

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P2860

The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors

http://www.wikidata.org/entity/Q24321690

description

2008 nî lūn-bûn

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2008 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հունիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

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J.CELL.2008.04.039

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The amyotrophic lateral sclero ...... as a ligand for Eph receptors

@en

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Anthony Zoghbi

http://www.w3.org/2001/XMLSchema#string

Chao Tong

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Claire Haueter

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Hiroshi Tsuda

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Hugo J Bellen

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Justin Kwan

http://www.w3.org/2001/XMLSchema#string

Kriti Mohan

http://www.w3.org/2001/XMLSchema#string

Michael A Miller

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Sung Min Han

http://www.w3.org/2001/XMLSchema#string

Yadollah Harati

http://www.w3.org/2001/XMLSchema#string

P2860

Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins

A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis.

Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP

The genetics of Caenorhabditis elegans

Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein

Unfolded protein response in a Drosophila model for retinal degeneration

Gene recruitment of the activated INO1 locus to the nuclear membrane

2.6 A resolution crystal structure of helices of the motile major sperm protein (MSP) of Caenorhabditis elegans

A highly conserved binding site in vesicle-associated membrane protein-associated protein (VAP) for the FFAT motif of lipid-binding proteins.

Role of the yeast VAP homolog, Scs2p, in INO1 expression and phospholipid metabolism.

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amyotrophic lateral sclerosis

Eph receptor A4

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