Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1
about
Identification and functional analysis of a new phosphorylation site (Y398) in the SH3 domain of Abi-1ABL tyrosine kinases: evolution of function, regulation, and specificityAbi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cellsRegulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contextsDifferential regulation of macropinocytosis by Abi1/Hssh3bp1 isoformsSH3 domains: modules of protein-protein interactions.Reciprocal regulation of Abl kinase by Crk Y251 and Abi1 controls invasive phenotypes in glioblastoma.The NESH/Abi-3-based WAVE2 complex is functionally distinct from the Abi-1-based WAVE2 complex.Functional mechanisms and roles of adaptor proteins in abl-regulated cytoskeletal actin dynamics.Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivationEnhancement of ABL kinase catalytic efficiency by a direct binding regulator is independent of other regulatory mechanisms.Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core.Essential role for Abi1 in embryonic survival and WAVE2 complex integrityDisruption of Abi1/Hssh3bp1 expression induces prostatic intraepithelial neoplasia in the conditional Abi1/Hssh3bp1 KO mice.Crk and ABI1: binary molecular switches that regulate abl tyrosine kinase and signaling to the cytoskeleton.Structure and dynamic regulation of Abl kinases.Abi1, a critical molecule coordinating actin cytoskeleton reorganization with PI-3 kinase and growth signaling.
P2860
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P2860
Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Allosteric inhibition of the n ...... des derived from Abi1/Hssh3bp1
@ast
Allosteric inhibition of the n ...... des derived from Abi1/Hssh3bp1
@en
Allosteric inhibition of the n ...... des derived from Abi1/Hssh3bp1
@en-gb
Allosteric inhibition of the n ...... des derived from Abi1/Hssh3bp1
@nl
type
label
Allosteric inhibition of the n ...... des derived from Abi1/Hssh3bp1
@ast
Allosteric inhibition of the n ...... des derived from Abi1/Hssh3bp1
@en
Allosteric inhibition of the n ...... des derived from Abi1/Hssh3bp1
@en-gb
Allosteric inhibition of the n ...... des derived from Abi1/Hssh3bp1
@nl
prefLabel
Allosteric inhibition of the n ...... des derived from Abi1/Hssh3bp1
@ast
Allosteric inhibition of the n ...... des derived from Abi1/Hssh3bp1
@en
Allosteric inhibition of the n ...... des derived from Abi1/Hssh3bp1
@en-gb
Allosteric inhibition of the n ...... des derived from Abi1/Hssh3bp1
@nl
P2093
P2860
P1476
Allosteric inhibition of the n ...... des derived from Abi1/Hssh3bp1
@en
P2093
Asim K Debnath
Brian Warner
Leszek Kotula
Sajjad Hossain
Xiaoling Xiong
Xinhua Guo
P2860
P304
P356
10.1016/J.BBAMCR.2008.01.028
P407
P577
2008-05-01T00:00:00Z