Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1
about
Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neuronsSerine-arginine protein kinases: a small protein kinase family with a large cellular presenceSplicing Regulators and Their Roles in Cancer Biology and TherapyConnecting the speckles: Splicing kinases and their role in tumorigenesis and treatment responseCell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentialsRegulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesisPotential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340)Bruchpilot in ribbon-like axonal agglomerates, behavioral defects, and early death in SRPK79D kinase mutants of Drosophila.Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.Multifaceted Regulation of Gene Expression by the Apoptosis- and Splicing-Associated Protein Complex and Its Components.Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigenThe SAP motif and C-terminal RS- and RD/E-rich region influences the sub-nuclear localization of Acinus isoforms.Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy.Abnormal expression of the pre-mRNA splicing regulators SRSF1, SRSF2, SRPK1 and SRPK2 in non small cell lung carcinoma.The N-terminal fragment from caspase-cleaved serine/arginine protein-specific kinase2 (SRPK2) translocates into the nucleus and promotes apoptosis.Regulating SR protein phosphorylation through regions outside the kinase domain of SRPK1Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance.NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 association.Dysregulation of splicing proteins in head and neck squamous cell carcinoma.Nuclear phosphoinositide signaling regulates messenger RNA export.The RNA-binding profile of Acinus, a peripheral component of the exon junction complex, reveals its role in splicing regulationSRPK1 Dissimilarly Impacts on the Growth, Metastasis, Chemosensitivity and Angiogenesis of Glioma in Normoxic and Hypoxic Conditions.Loss of aryl hydrocarbon receptor promotes gene changes associated with premature hematopoietic stem cell exhaustion and development of a myeloproliferative disorder in aging mice.miRNA pharmacogenomics: the new frontier for personalized medicine in cancer?Regulation of splicing by SR proteins and SR protein-specific kinases.Pharmacology of Modulators of Alternative Splicing.Functional Proteomics Identifies Acinus L as a Direct Insulin- and Amino Acid-Dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Substrate.Primary structural features of SR-like protein acinusS govern the phosphorylation mechanism by SRPK2.Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease.Molecular characterization and expression patterns of serine/arginine-rich specific kinase 3 (SPRK3) in porcine skeletal muscle.SRPK1 contributes to malignancy of hepatocellular carcinoma through a possible mechanism involving PI3K/Akt.Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine437.Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.Therapeutic Applications of Targeted Alternative Splicing to Cancer Treatment.
P2860
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P2860
Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Serine/arginine protein-specif ...... cinus and regulating cyclin A1
@ast
Serine/arginine protein-specif ...... cinus and regulating cyclin A1
@en
Serine/arginine protein-specif ...... cinus and regulating cyclin A1
@en-gb
Serine/arginine protein-specif ...... cinus and regulating cyclin A1
@nl
type
label
Serine/arginine protein-specif ...... cinus and regulating cyclin A1
@ast
Serine/arginine protein-specif ...... cinus and regulating cyclin A1
@en
Serine/arginine protein-specif ...... cinus and regulating cyclin A1
@en-gb
Serine/arginine protein-specif ...... cinus and regulating cyclin A1
@nl
prefLabel
Serine/arginine protein-specif ...... cinus and regulating cyclin A1
@ast
Serine/arginine protein-specif ...... cinus and regulating cyclin A1
@en
Serine/arginine protein-specif ...... cinus and regulating cyclin A1
@en-gb
Serine/arginine protein-specif ...... cinus and regulating cyclin A1
@nl
P2093
P2860
P921
P1433
P1476
Serine/arginine protein-specif ...... cinus and regulating cyclin A1
@en
P2093
Hanna Khoury
Keqiang Ye
Seung-Ju Yang
Shaozhong Dong
Sung-Wuk Jang
P2860
P304
P356
10.1158/0008-5472.CAN-08-0021
P407
P577
2008-06-15T00:00:00Z