Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. - Wikidata - wikimedia - TriplyDB

Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.

Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.

http://www.wikidata.org/entity/Q33605329

about

Posttranscriptional Regulation of Splicing Factor SRSF1 and Its Role in Cancer Cell Biology Splicing Regulators and Their Roles in Cancer Biology and Therapy The catalytic role of the M2 metal ion in PP2Cα Context-dependent control of alternative splicing by RNA-binding proteins A computational strategy to select optimized protein targets for drug development toward the control of cancer diseases Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340)Akt-ing up on SRPK1: oncogene or tumor suppressor?Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events.Expression of tumor necrosis factor-alpha-mediated genes predicts recurrence-free survival in lung cancer.Evidence for disulfide bonds in SR Protein Kinase 1 (SRPK1) that are required for activity and nuclear localization FANCI is a negative regulator of Akt activation.Whole-Genome Sequencing Reveals Genetic Variation in the Asian House Rat.BCLAF1 and its splicing regulator SRSF10 regulate the tumorigenic potential of colon cancer cells.PHLPP phosphatases as a therapeutic target in insulin resistance-related diseases.Plexin-B1 indirectly affects glioma invasiveness and angiogenesis by regulating the RhoA/αvβ3 signaling pathway and SRPK1.Ras-ling with new therapeutic targets for metastasis.Up-regulation of SRPK1 in non-small cell lung cancer promotes the growth and migration of cancer cells.Hepatic Tm6sf2 overexpression affects cellular ApoB-trafficking, plasma lipid levels, hepatic steatosis and atherosclerosis.Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes?The influence of SRPK1 on glioma apoptosis, metastasis, and angiogenesis through the PI3K/Akt signaling pathway under normoxia.Serine-arginine protein kinase 1 is associated with breast cancer progression and poor patient survival.Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells.Serine-arginine protein kinase 1 (SRPK1) is elevated in gastric cancer and plays oncogenic functions Genetic basis of octanoic acid resistance in Drosophila sechellia: functional analysis of a fine-mapped region.Both sides of the same coin: Rac1 splicing regulating by EGF signaling.hnRNPM guides an alternative splicing program in response to inhibition of the PI3K/AKT/mTOR pathway in Ewing sarcoma cells.hnRNP L controls HPV16 RNA polyadenylation and splicing in an Akt kinase-dependent manner.Loss of PRP4K drives anoikis resistance in part by dysregulation of epidermal growth factor receptor endosomal trafficking.Proteomics Analysis Identifies Orthologs of Human Chitinase-Like Proteins as Inducers of Tube Morphogenesis Defects in Drosophila melanogaster.FRZB and melusin, overexpressed in LGMD2A, regulate integrin β1D isoform replacement altering myoblast fusion and the integrin-signalling pathway.SRPK1 is a poor prognostic indicator and a novel potential therapeutic target for human colorectal cancer

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P2860

Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.

http://www.wikidata.org/entity/Q33605329

description

2014 nî lūn-bûn

@nan

2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի ապրիլին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Both decreased and increased S ...... ated dephosphorylation of Akt.

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Both decreased and increased S ...... ated dephosphorylation of Akt.

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type

label

Both decreased and increased S ...... ated dephosphorylation of Akt.

@ast

Both decreased and increased S ...... ated dephosphorylation of Akt.

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prefLabel

Both decreased and increased S ...... ated dephosphorylation of Akt.

@ast

Both decreased and increased S ...... ated dephosphorylation of Akt.

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J.MOLCEL.2014.03.007

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Both decreased and increased S ...... ated dephosphorylation of Akt.

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Anchang Hu

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Claudio Ponte de Albuquerque

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Curtis Harris

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Kun-Liang Guan

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Lixin Hong

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Masahiko Ajiro

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Michael Kruhlak

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Peiqing Sun

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Xiang-Dong Fu

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Zhi-Ming Zheng

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P2860

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior

SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells

Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons

Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

U1 snRNP determines mRNA length and regulates isoform expression

A novel role for shuttling SR proteins in mRNA translation

SR proteins in vertical integration of gene expression from transcription to RNA processing to translation

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Alexandra C. Newton

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