PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons
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Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondriaMitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cellsMitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagyThe role of oxidative stress in Parkinson's diseasePINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402PINK1 cleavage at position A103 by the mitochondrial protease PARL.Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fissionBAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradationOxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's diseaseNew insights into the role of mitochondria in aging: mitochondrial dynamics and moreMitochondria, calcium and cell death: a deadly triad in neurodegenerationParkinson's Disease: The Mitochondria-Iron LinkOxidative stress and Parkinson's diseaseRole of apoptosis in diseaseMitochondrial dysfunction and oxidative stress in Parkinson's diseaseEmerging modes of PINK1 signaling: another task for MARK2Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression.Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration.iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's diseaseParkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration.Mitochondrial Biology and Neurological DiseasesParkinson's disease as a result of agingMitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expressionEvidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1Mitochondria and quality control defects in a mouse model of Gaucher disease--links to Parkinson's diseaseMitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseasesMicrotubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transportHyperexcitable substantia nigra dopamine neurons in PINK1- and HtrA2/Omi-deficient mice.Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells.Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis.Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligaseIncreased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice.Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1.The neurogenic basic helix-loop-helix transcription factor NeuroD6 confers tolerance to oxidative stress by triggering an antioxidant response and sustaining the mitochondrial biomass.Parkinson's disease: insights from pathways.A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease.Neurodegenerative models in Drosophila: polyglutamine disorders, Parkinson disease, and amyotrophic lateral sclerosis.Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase AHuman DJ-1-specific transcriptional activation of tyrosine hydroxylase gene
P2860
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P2860
PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons
description
2008 nî lūn-bûn
@nan
2008 թուականին հրատարակուած գիտական յօդուած
@hyw
2008 թվականին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
PINK1 is necessary for long te ...... in human dopaminergic neurons
@ast
PINK1 is necessary for long te ...... in human dopaminergic neurons
@en
PINK1 is necessary for long te ...... in human dopaminergic neurons
@en-gb
PINK1 is necessary for long te ...... in human dopaminergic neurons
@nl
type
label
PINK1 is necessary for long te ...... in human dopaminergic neurons
@ast
PINK1 is necessary for long te ...... in human dopaminergic neurons
@en
PINK1 is necessary for long te ...... in human dopaminergic neurons
@en-gb
PINK1 is necessary for long te ...... in human dopaminergic neurons
@nl
prefLabel
PINK1 is necessary for long te ...... in human dopaminergic neurons
@ast
PINK1 is necessary for long te ...... in human dopaminergic neurons
@en
PINK1 is necessary for long te ...... in human dopaminergic neurons
@en-gb
PINK1 is necessary for long te ...... in human dopaminergic neurons
@nl
P2860
P50
P921
P3181
P1433
P1476
PINK1 is necessary for long te ...... in human dopaminergic neurons
@en
P2093
Andrey S Y Abramov
P2860
P3181
P356
10.1371/JOURNAL.PONE.0002455
P4011
90e9ebbbebd2803a38ae1e759e46504f85e62d4f
P407
P50
P577
2008-01-01T00:00:00Z