V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins
about
HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoterHigh mobility group protein-1 (HMG-1) is a unique activator of p53The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2Direct in vivo VH to JH rearrangement violating the 12/23 rule.Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsisPutting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1Recombination-activating gene proteins: more regulation, pleaseHMG-box domain stimulation of RAG1/2 cleavage activity is metal ion dependent.HMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex.HMGB1: roles in base excision repair and related function.DNA hairpin opening mediated by the RAG1 and RAG2 proteins.Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins.Functional analysis of coordinated cleavage in V(D)J recombination.HMGB1: the jack-of-all-trades protein is a master DNA repair mechanic.Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking.A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination.Mechanistic basis for coding end sequence effects in the initiation of V(D)J recombinationConditional RAG-1 mutants block the hairpin formation step of V(D)J recombination.A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.Functional organization of single and paired V(D)J cleavage complexesRAG transposase can capture and commit to target DNA before or after donor cleavageThe RAG proteins in V(D)J recombination: more than just a nuclease.Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinaseRAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes.Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage.Identification and characterization of a gain-of-function RAG-1 mutant.In vivo transposition mediated by V(D)J recombinase in human T lymphocytes.Base flipping in V(D)J recombination: insights into the mechanism of hairpin formation, the 12/23 rule, and the coordination of double-strand breaksThe architecture of the 12RSS in V(D)J recombination signal and synaptic complexes.Requirements for DNA hairpin formation by RAG1/2The bounty of RAGs: recombination signal complexes and reaction outcomes.New concepts in the regulation of an ancient reaction: transposition by RAG1/RAG2.N-terminal RAG1 frameshift mutations in Omenn's syndrome: internal methionine usage leads to partial V(D)J recombination activity and reveals a fundamental role in vivo for the N-terminal domains.Fluorescence resonance energy transfer analysis of recombination signal sequence configuration in the RAG1/2 synaptic complex.V(D)J recombination: in vitro coding joint formation.Quantitative analyses of RAG-RSS interactions and conformations revealed by atomic force microscopy.Immunoglobulin expression in non-lymphoid lineage and neoplastic cells.A zinc site in the C-terminal domain of RAG1 is essential for DNA cleavage activity.Synapsis of recombination signal sequences located in cis and DNA underwinding in V(D)J recombination.The nicking step in V(D)J recombination is independent of synapsis: implications for the immune repertoire
P2860
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P2860
V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
V(D)J recombination: modulatio ...... tract and DNA-bending proteins
@ast
V(D)J recombination: modulatio ...... tract and DNA-bending proteins
@en
V(D)J recombination: modulatio ...... tract and DNA-bending proteins
@en-gb
V(D)J recombination: modulatio ...... tract and DNA-bending proteins
@nl
type
label
V(D)J recombination: modulatio ...... tract and DNA-bending proteins
@ast
V(D)J recombination: modulatio ...... tract and DNA-bending proteins
@en
V(D)J recombination: modulatio ...... tract and DNA-bending proteins
@en-gb
V(D)J recombination: modulatio ...... tract and DNA-bending proteins
@nl
prefLabel
V(D)J recombination: modulatio ...... tract and DNA-bending proteins
@ast
V(D)J recombination: modulatio ...... tract and DNA-bending proteins
@en
V(D)J recombination: modulatio ...... tract and DNA-bending proteins
@en-gb
V(D)J recombination: modulatio ...... tract and DNA-bending proteins
@nl
P2093
P2860
P356
P1476
V(D)J recombination: modulatio ...... tract and DNA-bending proteins
@en
P2093
P2860
P304
P356
10.1084/JEM.185.11.2025
P407
P577
1997-06-02T00:00:00Z