The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2
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TOX defines a conserved subfamily of HMG-box proteinsAssociation of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomesBorna disease virus phosphoprotein represses p53-mediated transcriptional activity by interference with HMGB1The DNA-binding region of RAG 1 is not a homeodomain.High affinity binding of proteins HMG1 and HMG2 to semicatenated DNA loopsStructure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsisStructural Analysis of HMGD–DNA Complexes Reveals Influence of Intercalation on Sequence Selectivity and DNA BendingModulation of the DNA-binding activity of Saccharomyces cerevisiae MSH2-MSH6 complex by the high-mobility group protein NHP6A, in vitroSuperactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteinsHMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequencesPutting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1Comparative analysis of the influence of the high-mobility group box 1 protein on DNA binding and transcriptional activation by the androgen, glucocorticoid, progesterone and mineralocorticoid receptorsAging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritisDNA binding by single HMG box model proteins.Crystal structure of the V(D)J recombinase RAG1-RAG2HMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex.Mechanism for specificity by HMG-1 in enhanceosome assemblyMutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficienciesThe DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombinationA C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.The RAG proteins in V(D)J recombination: more than just a nuclease.The DNA architectural protein HMGB1 displays two distinct modes of action that promote enhanceosome assembly.A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals.RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes.HMGB1 in health and disease.Suppressed catalytic activity of base excision repair enzymes on rotationally positioned uracil in nucleosomes.The bounty of RAGs: recombination signal complexes and reaction outcomes.N-terminal RAG1 frameshift mutations in Omenn's syndrome: internal methionine usage leads to partial V(D)J recombination activity and reveals a fundamental role in vivo for the N-terminal domains.Fluorescence resonance energy transfer analysis of recombination signal sequence configuration in the RAG1/2 synaptic complex.Nucleosome dynamics: HMGB1 relaxes canonical nucleosome structure to facilitate estrogen receptor binding.Prospective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modeling.Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA.Requirement of TCTG(G/C) Direct Repeats and Overlapping GATA Site for Maintaining the Cardiac-Specific Expression of Cardiac troponin T in Developing and Adult Mice.Quantitative analyses of RAG-RSS interactions and conformations revealed by atomic force microscopy.Langerhans cell protein 1 (LCP1) binds to PNUTS in the nucleus: implications for this complex in transcriptional regulation.Initial stages of V(D)J recombination: the organization of RAG1/2 and RSS DNA in the postcleavage complex.Molecular mechanism underlying RAG1/RAG2 synaptic complex formation.A zinc site in the C-terminal domain of RAG1 is essential for DNA cleavage activity.β-Catenin induces T-cell transformation by promoting genomic instability.Synapsis of recombination signal sequences located in cis and DNA underwinding in V(D)J recombination.
P2860
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P2860
The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The RAG1 homeodomain recruits ...... -bending activity of RAG1-RAG2
@ast
The RAG1 homeodomain recruits ...... -bending activity of RAG1-RAG2
@en
The RAG1 homeodomain recruits ...... -bending activity of RAG1-RAG2
@nl
type
label
The RAG1 homeodomain recruits ...... -bending activity of RAG1-RAG2
@ast
The RAG1 homeodomain recruits ...... -bending activity of RAG1-RAG2
@en
The RAG1 homeodomain recruits ...... -bending activity of RAG1-RAG2
@nl
prefLabel
The RAG1 homeodomain recruits ...... -bending activity of RAG1-RAG2
@ast
The RAG1 homeodomain recruits ...... -bending activity of RAG1-RAG2
@en
The RAG1 homeodomain recruits ...... -bending activity of RAG1-RAG2
@nl
P2093
P2860
P356
P1476
The RAG1 homeodomain recruits ...... -bending activity of RAG1-RAG2
@en
P2093
E Spanopoulou
M Beltrame
M E Bianchi
S Santagata
P2860
P304
P356
10.1128/MCB.19.10.6532
P407
P577
1999-10-01T00:00:00Z