UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
about
The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complexSystematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networksAPC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachmentLys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase CezanneMaintaining Genome Stability in Defiance of Mitotic DNA DamageThe recognition of ubiquitinated proteins by the proteasomeK11-linked ubiquitin chains as novel regulators of cell divisionThe zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylationA Dual E3 Mechanism for Rub1 Ligation to Cdc53E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6Structural analysis of human Cdc20 supports multisite degron recognition by APC/CElectron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdownCryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin LigationThe APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.Spatiotemporal regulation of the anaphase-promoting complex in mitosisCrystal Structure of a Ube2S-Ubiquitin ConjugateSystematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functionsMicrotubule-dependent regulation of mitotic protein degradation.Molecular basis of APC/C regulation by the spindle assembly checkpoint.UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complexOverexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.Enhanced protein degradation by branched ubiquitin chains.A high-throughput platform for lentiviral overexpression screening of the human ORFeome.The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium.How cyclin A destruction escapes the spindle assembly checkpoint.Spindle checkpoint silencing: ensuring rapid and concerted anaphase onsetMutual antagonism between the anaphase promoting complex and the spindle assembly checkpoint contributes to mitotic timing in Caenorhabditis elegansCohesion fatigue explains why pharmacological inhibition of the APC/C induces a spindle checkpoint-dependent mitotic arrestCezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner.Improved quantitative mass spectrometry methods for characterizing complex ubiquitin signals.A gene expression and pre-mRNA splicing signature that marks the adenoma-adenocarcinoma progression in colorectal cancer.Caspase activity is not required for the mitotic checkpoint or mitotic slippage in human cells.APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.High-throughput quantitative proteomic analysis of dengue virus type 2 infected A549 cells.Global gene expression analysis of canine cutaneous mast cell tumor: could molecular profiling be useful for subtype classification and prognostication?Regulated inactivation of the spindle assembly checkpoint without functional mitotic spindles.The biochemistry of mitosisUbiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope.Substrate degradation by the anaphase promoting complex occurs during mitotic slippage.
P2860
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P2860
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
@ast
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
@en
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
@en-gb
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
@nl
type
label
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
@ast
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
@en
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
@en-gb
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
@nl
prefLabel
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
@ast
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
@en
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
@en-gb
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
@en
P2093
Ashok R Venkitaraman
Colin Godwin
Mathew J Garnett
Paul Russell
Takahiro Matsusaka
P2860
P2888
P304
P3181
P356
10.1038/NCB1983
P407
P577
2009-11-01T00:00:00Z
P5875
P6179
1024221675