Structural analysis of human Cdc20 supports multisite degron recognition by APC/C
about
Dual control by Cdk1 phosphorylation of the budding yeast APC/C ubiquitin ligase activator Cdh1Bub3-BubR1-dependent sequestration of Cdc20Fizzy at DNA breaks facilitates the correct segregation of broken chromosomesThe zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylationInsights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 ComplexElectron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdownCryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin LigationSpatiotemporal regulation of the anaphase-promoting complex in mitosisMicrotubule-dependent regulation of mitotic protein degradation.Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.Insights into the cellular mechanism of the yeast ubiquitin ligase APC/C-Cdh1 from the analysis of in vivo degrons.Molecular architecture and mechanism of the anaphase-promoting complexMolecular mechanism of APC/C activation by mitotic phosphorylation.Molecular basis of APC/C regulation by the spindle assembly checkpoint.How chromosome mis-segregation leads to cancer: lessons from BubR1 mouse modelsStructure-biological function relationship extended to mitotic arrest-deficient 2-like protein Mad2 native and mutants-new opportunity for genetic disorder control.The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis.Spatial regulation of the spindle assembly checkpoint and anaphase-promoting complex in Aspergillus nidulansRING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complexControl of APC/C-dependent ubiquitin chain elongation by reversible phosphorylationStructural Basis for Substrate Selectivity of the E3 Ligase COP1Substrate Recognition by the Cdh1 Destruction Box Receptor Is a General Requirement for APC/CCdh1-mediated ProteolysisAssociation between polymorphisms in segregation genes BUB1B and TTK and gastric cancer riskA novel mutation in the N-terminal domain of Drosophila BubR1 affects the spindle assembly checkpoint function of BubR1.APC/CCDC20 and APC/C play pivotal roles in the process of embryonic development in Artemia sinica.Co-regulation proteomics reveals substrates and mechanisms of APC/C-dependent degradation.Panta rhei: the APC/C at steady state.The Multifunctions of WD40 Proteins in Genome Integrity and Cell Cycle Progression.Potential therapeutic targets and small molecular drugs for pediatric B-precursor acute lymphoblastic leukemia treatment based on microarray dataThe Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex.Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.The mitotic checkpoint complex (MCC): looking back and forth after 15 years.Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.The internal Cdc20 binding site in BubR1 facilitates both spindle assembly checkpoint signalling and silencing.The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/CA structural model of the anaphase promoting complex co-activator (Cdh1) and in silico design of inhibitory compounds.The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulatorsThe D box meets its match.Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).R383C mutation of human CDC20 results in idiopathic non-obstructive azoospermia.
P2860
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P2860
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C
@ast
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C
@en
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C
@nl
type
label
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C
@ast
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C
@en
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C
@nl
prefLabel
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C
@ast
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C
@en
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C
@nl
P2093
P2860
P3181
P356
P1476
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C
@en
P2093
Hongtao Yu
Ross Warrington
Xuelian Luo
P2860
P304
P3181
P356
10.1073/PNAS.1213438109
P407
P577
2012-11-06T00:00:00Z