Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity
about
From gene discovery to new biological mechanisms: heparanases and congenital urinary bladder diseaseInvolvement of heparanase in atherosclerosis and other vessel wall pathologiesLRIG2 mutations cause urofacial syndromeA mouse model of urofacial syndrome with dysfunctional urinationMechanisms of heparanase inhibitors in cancer therapy.Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and α-actinin.Clinical significance of heparanase splice variant (t5) in renal cell carcinoma: evaluation by a novel t5-specific monoclonal antibodySpecific genes involved in synthesis and editing of heparan sulfate proteoglycans show altered expression patterns in breast cancerUrinary tract effects of HPSE2 mutations.Gene expression profiling leads to discovery of correlation of matrix metalloproteinase 11 and heparanase 2 in breast cancer progression.Heparan sulfate proteoglycans undergo differential expression alterations in right sided colorectal cancer, depending on their metastatic character.The Profile of Heparanase Expression Distinguishes Differentiated Thyroid Carcinoma from Benign Neoplasms.Heparanase induces signal transducer and activator of transcription (STAT) protein phosphorylation: preclinical and clinical significance in head and neck cancerCommon cancer in a wild animal: the California sea lion (Zalophus californianus) as an emerging model for carcinogenesisSignificance of heparanase in cancer and inflammation.Heparanase localization during palatogenesis in mice.Immunohistochemical expression of heparanase isoforms and syndecan-1 proteins in colorectal adenomas.Heparanase 2 Attenuates Head and Neck Tumor Vascularity and Growth.Heparanase 2 expression inversely correlates with bladder carcinoma grade and stage.The prognostic significance of heparanase expression in metastatic melanomaHeparanase in inflammation and inflammation-associated cancer.Genetics of human congenital urinary bladder disease.Urofacial syndrome: a genetic and congenital disease of aberrant urinary bladder innervation.Molecular model of human heparanase with proposed binding mode of a heparan sulfate oligosaccharide and catalytic amino acids.Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-β-D-glucuronidase (heparanase).Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases.Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease.Epigenetic Regulation of the Biosynthesis & Enzymatic Modification of Heparan Sulfate Proteoglycans: Implications for Tumorigenesis and Cancer Biomarkers.Extracellular matrix alterations in the Peyronie's disease.Heparan sulfate proteoglycans and heparanases in Alzheimer's disease: current outlook and potential therapeutic targets.Extracellular matrix remodeling in experimental intervertebral disc degeneration.Heparanase 2, mutated in urofacial syndrome, mediates peripheral neural development in Xenopus.Heparanase: From basic research to therapeutic applications in cancer and inflammation.Molecular characterization, expression profiles, and association analysis with hematologic parameters of the porcine HPSE and HPSE2 genes.Activated HGF-c-Met Axis in Head and Neck Cancer.Opposing Functions of Heparanase-1 and Heparanase-2 in Cancer Progression.Heparanase Overexpresses in Keratoconic Cornea and Tears Depending on the Pathologic Grade.Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.Upregulated Expression of Heparanase and Heparanase 2 in the Brains of Alzheimer's Disease.Evidence for a genetic basis of urogenital carcinoma in the wild California sea lion.
P2860
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P2860
Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Heparanase 2 interacts with he ...... d inhibits heparanase activity
@ast
Heparanase 2 interacts with he ...... d inhibits heparanase activity
@en
Heparanase 2 interacts with he ...... d inhibits heparanase activity
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Heparanase 2 interacts with he ...... d inhibits heparanase activity
@nl
type
label
Heparanase 2 interacts with he ...... d inhibits heparanase activity
@ast
Heparanase 2 interacts with he ...... d inhibits heparanase activity
@en
Heparanase 2 interacts with he ...... d inhibits heparanase activity
@en-gb
Heparanase 2 interacts with he ...... d inhibits heparanase activity
@nl
prefLabel
Heparanase 2 interacts with he ...... d inhibits heparanase activity
@ast
Heparanase 2 interacts with he ...... d inhibits heparanase activity
@en
Heparanase 2 interacts with he ...... d inhibits heparanase activity
@en-gb
Heparanase 2 interacts with he ...... d inhibits heparanase activity
@nl
P2093
P2860
P50
P921
P356
P1476
Heparanase 2 interacts with he ...... d inhibits heparanase activity
@en
P2093
Anna Shteingauz
Flonia Levy-Adam
Gil Arvatz
Ilana Doweck
Inna Naroditsky
Miriam Gross
Victoria Cohen-Kaplan
P2860
P304
P356
10.1074/JBC.M110.116384
P407
P577
2010-09-03T00:00:00Z