EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells - Wikidata - wikimedia - TriplyDB

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

http://www.wikidata.org/entity/Q24672969

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Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression Polycomb group genes: keeping stem cell activity in balance Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27 Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2 Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity Regulation of DU145 prostate cancer cell growth by Scm-like with four mbt domains 2 Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity BRCA1 is a negative modulator of the PRC2 complex miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis Epigenetic transcriptional repression of cellular genes by a viral SET protein HOTAIR: Flight of noncoding RNAs in cancer metastasis EZH2 methyltransferase and H3K27 methylation in breast cancer Regulation of chromatin by histone modifications Golgi protein GOLM1 is a tissue and urine biomarker of prostate cancer Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins Prognostic meta-signature of breast cancer developed by two-stage mixture modeling of microarray data The SET-domain protein superfamily: protein lysine methyltransferases Internet-based Profiler system as integrative framework to support translational research.Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives Post-translational modification-regulated leukocyte adhesion and migration Targeting EZH2 in cancer The role of the oncofetal H19 lncRNA in tumor metastasis: orchestrating the EMT-MET decision EZH2 in normal hematopoiesis and hematological malignancies Synthesis of lysine methyltransferase inhibitors PRC2 during vertebrate organogenesis: a complex in transition Chemical probes of histone lysine methyltransferases Common features of chromatin in aging and cancer: cause or coincidence?Epigenetics in breast cancer: what's new?Chromatin targeting drugs in cancer and immunity Gain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic intervention

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EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

http://www.wikidata.org/entity/Q24672969

description

2003 nî lūn-bûn

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2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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Proceedings of the National Academy of Sciences of the United States of America

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Arie P Otte

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Arul M Chinnaiyan

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Celina G Kleer

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Daniel F Hayes

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Donna Livant

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Ichiro Ota

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Mark A Rubin

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Michael S Sabel

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Qi Cao

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Richard G A B Sewalt

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P2860

The Hallmarks of Cancer

The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3

Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes.

Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres

Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins.

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

Gene expression profiling predicts clinical outcome of breast cancer

Molecular portraits of human breast tumours

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation

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