Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein - Wikidata - wikimedia - TriplyDB

Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein

Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein

http://www.wikidata.org/entity/Q24336515

about

Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains.The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein Cytoplasmic domain of the beta-amyloid protein precursor of Alzheimer's disease: function, regulation of proteolysis, and implications for drug development Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage LRP: a multifunctional scavenger and signaling receptor Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.Identification and characterization of a neuronal enriched novel transcript encoding the previously described p60Fe65 isoform.Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration.The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis.Regulated proteolysis of APP and ApoE receptors.Ubiquitylation of Fe65 adaptor protein by neuronal precursor cell expressed developmentally down regulated 4-2 (Nedd4-2) via the WW domain interaction with Fe65.The physiology of the β-amyloid precursor protein intracellular domain AICD.Fe65 matters: new light on an old molecule.Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases.APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins.Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein.Fe65 is not involved in the platelet-derived growth factor-induced processing of Alzheimer's amyloid precursor protein, which activates its caspase-directed cleavage.hFE65L influences amyloid precursor protein maturation and secretion.Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration Using biological networks to search for interacting loci in genome-wide association studies.The amyloid precursor protein intracellular domain-fe65 multiprotein complexes: a challenge to the amyloid hypothesis for Alzheimer's disease?Mutation of the feh-1 gene, the Caenorhabditis elegans orthologue of mammalian Fe65, decreases the expression of two acetylcholinesterase genes.The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice.Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain.Expression of human FE65 in amyloid precursor protein transgenic mice is associated with a reduction in beta-amyloid load.A differential proteomic approach reveals an evolutionary conserved regulation of Nme proteins by Fe65 in C. elegans and mouse.Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1.

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P2860

Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein

http://www.wikidata.org/entity/Q24336515

description

1998 nî lūn-bûn

@nan

1998 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի փետրվարին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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name

Fe65L2: a new member of the Fe ...... beta-amyloid precursor protein

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Fe65L2: a new member of the Fe ...... beta-amyloid precursor protein

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Fe65L2: a new member of the Fe ...... beta-amyloid precursor protein

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Fe65L2: a new member of the Fe ...... beta-amyloid precursor protein

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Fe65L2: a new member of the Fe ...... beta-amyloid precursor protein

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Fe65L2: a new member of the Fe ...... beta-amyloid precursor protein

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Fe65L2: a new member of the Fe ...... beta-amyloid precursor protein

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Fe65L2: a new member of the Fe ...... beta-amyloid precursor protein

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Fe65L2: a new member of the Fe ...... beta-amyloid precursor protein

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Fe65L2: a new member of the Fe ...... beta-amyloid precursor protein

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Fe65L2: a new member of the Fe ...... beta-amyloid precursor protein

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Fe65L2: a new member of the Fe ...... beta-amyloid precursor protein

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P1433

Biochemical Journal

P1476

Fe65L2: a new member of the Fe ...... beta-amyloid precursor protein

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P2093

A Duilio

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G Minopoli

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N Zambrano

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R Faraonio

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T Russo

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P2860

APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein

Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein

The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier

Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain

Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease.

A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.

The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein.

P304

513-9

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P31

scholarly article

P356

10.1042/BJ3300513

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P407

P478

330 ( Pt 1)

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P577

1998-02-15T00:00:00Z

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P5875

13768412

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P698

9461550

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P921

Alzheimer's disease

P932

1219167

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