Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains
about
Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain developmentA TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesisNovel modulators of amyloid-beta precursor protein processing.Substrate specificity of gamma-secretase and other intramembrane proteases.Ubiquitylation of Fe65 adaptor protein by neuronal precursor cell expressed developmentally down regulated 4-2 (Nedd4-2) via the WW domain interaction with Fe65.The inhibition of 45A ncRNA expression reduces tumor formation, affecting tumor nodules compactness and metastatic potential in neuroblastoma cells.It all starts at the ends: multifaceted involvement of C- and N-terminally modified cholinesterases in Alzheimer's disease.Endoproteolytic cleavage of FE65 converts the adaptor protein to a potent suppressor of the sAPPalpha pathway in primates.Expression of human FE65 in amyloid precursor protein transgenic mice is associated with a reduction in beta-amyloid load.
P2860
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P2860
Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Characterization of an amyloid ...... hotyrosine-interaction domains
@ast
Characterization of an amyloid ...... hotyrosine-interaction domains
@en
Characterization of an amyloid ...... hotyrosine-interaction domains
@en-gb
Characterization of an amyloid ...... hotyrosine-interaction domains
@nl
type
label
Characterization of an amyloid ...... hotyrosine-interaction domains
@ast
Characterization of an amyloid ...... hotyrosine-interaction domains
@en
Characterization of an amyloid ...... hotyrosine-interaction domains
@en-gb
Characterization of an amyloid ...... hotyrosine-interaction domains
@nl
prefLabel
Characterization of an amyloid ...... hotyrosine-interaction domains
@ast
Characterization of an amyloid ...... hotyrosine-interaction domains
@en
Characterization of an amyloid ...... hotyrosine-interaction domains
@en-gb
Characterization of an amyloid ...... hotyrosine-interaction domains
@nl
P2860
P356
P1433
P1476
Characterization of an amyloid ...... hotyrosine-interaction domains
@en
P2093
Hiroshi Tanahashi
Takeshi Tabira
P2860
P304
P356
10.1042/BJ20020562
P407
P577
2002-11-01T00:00:00Z