MdmX is a substrate for the deubiquitinating enzyme USP2a
about
Role of MXD3 in proliferation of DAOY human medulloblastoma cellsPositive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1A synthetic form of frizzled 8-associated antiproliferative factor enhances p53 stability through USP2a and MDM2EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma.Ubiquitin-specific cysteine protease 2a (USP2a) regulates the stability of Aurora-A.The p53 orchestra: Mdm2 and Mdmx set the toneMicroRNA-34a modulates MDM4 expression via a target site in the open reading frameABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53.Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets.Regulation of the DNA damage response by ubiquitin conjugation.The deubiquitinating enzyme USP24 is a regulator of the UV damage response.Identifying USPs regulating immune signals in Drosophila: USP2 deubiquitinates Imd and promotes its degradation by interacting with the proteasomeAssess the expression of ubiquitin specific protease USP2a for bladder cancer diagnosisPeroxisomal Import Reduces the Proapoptotic Activity of Deubiquitinating Enzyme USP2The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer.USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signalsThe Ubiquitin Proteasome Pathway (UPP) in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesisThe presence of wild type p53 in hematological cancers improves the efficacy of combinational therapy targeting metabolismUSP2a alters chemotherapeutic response by modulating redox.The ubiquitin-specific protease USP2a prevents endocytosis-mediated EGFR degradation.Monoubiquitination is critical for ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and stabilize p53 protein.Ubiquitin-specific peptidase 48 regulates Mdm2 protein levels independent of its deubiquitinase activity.Mdm2 and MdmX partner to regulate p53.Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy.A portrayal of E3 ubiquitin ligases and deubiquitylases in cancer.Deubiquitylating enzymes and DNA damage response pathways.Cell death and deubiquitinases: perspectives in cancer.Deubiquitinases and the new therapeutic opportunities offered to cancer.Regulation of MDM2 Stability After DNA Damage.Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondriaMDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond.Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges.Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma.USP2a negatively regulates IL-1β- and virus-induced NF-κB activation by deubiquitinating TRAF6.Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a.Ubiquitin-specific protease 2 decreases p53-dependent apoptosis in cutaneous T-cell lymphoma.p53 is activated in response to disruption of the pre-mRNA splicing machinery.Regulation of TP53 Degradation
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MdmX is a substrate for the deubiquitinating enzyme USP2a
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
MdmX is a substrate for the deubiquitinating enzyme USP2a
@ast
MdmX is a substrate for the deubiquitinating enzyme USP2a
@en
MdmX is a substrate for the deubiquitinating enzyme USP2a
@en-gb
MdmX is a substrate for the deubiquitinating enzyme USP2a
@nl
type
label
MdmX is a substrate for the deubiquitinating enzyme USP2a
@ast
MdmX is a substrate for the deubiquitinating enzyme USP2a
@en
MdmX is a substrate for the deubiquitinating enzyme USP2a
@en-gb
MdmX is a substrate for the deubiquitinating enzyme USP2a
@nl
prefLabel
MdmX is a substrate for the deubiquitinating enzyme USP2a
@ast
MdmX is a substrate for the deubiquitinating enzyme USP2a
@en
MdmX is a substrate for the deubiquitinating enzyme USP2a
@en-gb
MdmX is a substrate for the deubiquitinating enzyme USP2a
@nl
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P2860
P921
P3181
P356
P1433
P1476
MdmX is a substrate for the deubiquitinating enzyme USP2a
@en
P2093
M K Saville
N Allende-Vega
P2860
P2888
P304
P3181
P356
10.1038/ONC.2009.330
P407
P577
2010-01-21T00:00:00Z
P5875
P6179
1034463028