p53 is activated in response to disruption of the pre-mRNA splicing machinery. - Wikidata - wikimedia - TriplyDB

p53 is activated in response to disruption of the pre-mRNA splicing machinery.

p53 is activated in response to disruption of the pre-mRNA splicing machinery.

http://www.wikidata.org/entity/Q44950735

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Modification by ubiquitin-like proteins: significance in apoptosis and autophagy pathways Modulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response.MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame PRPF8 defects cause missplicing in myeloid malignancies.Variants affecting exon skipping contribute to complex traits.Molecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo.Detained introns are a novel, widespread class of post-transcriptionally spliced introns.ROS and p53 in regulation of UVB-induced HDM2 alternative splicing Alternative splicing of NUMB, APP and VEGFA as the features of pancreatic ductal carcinoma.Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals.Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma.Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery Oncogenic alternative splicing switches: role in cancer progression and prospects for therapy.Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs.The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.A genome-wide siRNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment.The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a.The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway A small molecule drug promoting miRNA processing induces alternative splicing of MdmX transcript and rescues p53 activity in human cancer cells overexpressing MdmX protein Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome.Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity.Inhibition of Casein Kinase 2 Protects Oligodendrocytes From Excitotoxicity by Attenuating JNK/p53 Signaling Cascade

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P2860

p53 is activated in response to disruption of the pre-mRNA splicing machinery.

http://www.wikidata.org/entity/Q44950735

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年学术文章

@wuu

2012年学术文章

@zh-cn

2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

2012年學術文章

@zh

2012年學術文章

@zh-hant

name

p53 is activated in response to disruption of the pre-mRNA splicing machinery.

@en

p53 is activated in response to disruption of the pre-mRNA splicing machinery.

@nl

type

label

p53 is activated in response to disruption of the pre-mRNA splicing machinery.

@en

p53 is activated in response to disruption of the pre-mRNA splicing machinery.

@nl

prefLabel

p53 is activated in response to disruption of the pre-mRNA splicing machinery.

@en

p53 is activated in response to disruption of the pre-mRNA splicing machinery.

@nl

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p53 is activated in response to disruption of the pre-mRNA splicing machinery

@en

P2093

A Sparks

http://www.w3.org/2001/XMLSchema#string

M K Saville

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S Dayal

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U Agarwala

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P2860

The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

RNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodies

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53

p53 isoforms can regulate p53 transcriptional activity.

Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast

MdmX is a substrate for the deubiquitinating enzyme USP2a

The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes

Prp8 protein: at the heart of the spliceosome

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1-14

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scholarly article

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10.1038/ONC.2012.38

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1

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32

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Jean-Christophe Bourdon

Nerea Allende-Vega

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2012-02-20T00:00:00Z

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221847115

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22349816

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