Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis
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Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene-disrupted miceLipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolasePseudomonas aeruginosa Cif defines a distinct class of α/β epoxide hydrolases utilizing a His/Tyr ring-opening pairImpact of soluble epoxide hydrolase and epoxyeicosanoids on human healthThe molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitorSynthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase ISynthesis and structure–activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitorsInhibition of soluble epoxide hydrolase by fulvestrant and sulfoxidesFragment Screening of Soluble Epoxide Hydrolase for Lead Generation-Structure-Based Hit Evaluation and Chemistry ExplorationSoluble epoxide hydrolase: A potential target for metabolic diseasesSoluble epoxide hydrolase: gene structure, expression and deletionSoluble epoxide hydrolase inhibitors and heart failureOpposite effects of gene deficiency and pharmacological inhibition of soluble epoxide hydrolase on cardiac fibrosisEffect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formationHeavy chain single-domain antibodies to detect native human soluble epoxide hydrolaseInhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine modelDevelopment of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted librariesMethod for Sorting and Pairwise Selection of Nanobodies for the Development of Highly Sensitive Sandwich ImmunoassaysThe cloning and characterization of a soluble epoxide hydrolase in chicken.X-ray structure of potato epoxide hydrolase sheds light on substrate specificity in plant enzymes.Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids.The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivativesThe role of epoxide hydrolases in health and disease.Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates.Role of soluble epoxide hydrolase in age-related vascular cognitive decline.Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta.Soluble epoxide hydrolase as an anti-inflammatory target of the thrombolytic stroke drug SMTP-7Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology.Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolaseSoluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs).Förster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase.Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo.Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis.Design and discovery of soluble epoxide hydrolase inhibitors for the treatment of cardiovascular diseases.Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase.Microsomal cytochrome P450 as a target for drug discovery and repurposing.Soluble epoxide hydrolase homologs in Strongylocentrotus purpuratus suggest a gene duplication event and subsequent divergence.Lysophosphatidic acids are new substrates for the phosphatase domain of soluble epoxide hydrolasePeptidyl-urea based inhibitors of soluble epoxide hydrolases.Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids
P2860
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P2860
Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis
description
2004 nî lūn-bûn
@nan
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Structure of human epoxide hyd ...... and phosphate ester hydrolysis
@ast
Structure of human epoxide hyd ...... and phosphate ester hydrolysis
@en
Structure of human epoxide hyd ...... and phosphate ester hydrolysis
@en-gb
Structure of human epoxide hyd ...... and phosphate ester hydrolysis
@nl
type
label
Structure of human epoxide hyd ...... and phosphate ester hydrolysis
@ast
Structure of human epoxide hyd ...... and phosphate ester hydrolysis
@en
Structure of human epoxide hyd ...... and phosphate ester hydrolysis
@en-gb
Structure of human epoxide hyd ...... and phosphate ester hydrolysis
@nl
prefLabel
Structure of human epoxide hyd ...... and phosphate ester hydrolysis
@ast
Structure of human epoxide hyd ...... and phosphate ester hydrolysis
@en
Structure of human epoxide hyd ...... and phosphate ester hydrolysis
@en-gb
Structure of human epoxide hyd ...... and phosphate ester hydrolysis
@nl
P921
P356
P1433
P1476
Structure of human epoxide hyd ...... and phosphate ester hydrolysis
@en
P2093
David W Christianson
German A Gomez
P304
P356
10.1021/BI036189J
P407
P577
2004-04-27T00:00:00Z