Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). - Wikidata - wikimedia - TriplyDB

Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs).

Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs).

http://www.wikidata.org/entity/Q36681676

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Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception Eicosanoid storm in infection and inflammation Mechanism of the sex difference in endothelial dysfunction after stroke Gamma-linolenic and stearidonic acids are required for basal immunity in Caenorhabditis elegans through their effects on p38 MAP kinase activity Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling The role of epoxyeicosatrienoic acids in the cardiovascular system Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer Estrogen, aging and the cardiovascular system Soluble epoxide hydrolase inhibitors and heart failure Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase Soluble Epoxide Hydrolase Inhibition: Targeting Multiple Mechanisms of Ischemic Brain Injury with a Single Agent Bioactive lipid profiling reveals drug target engagement of a soluble epoxide hydrolase inhibitor in a murine model of tobacco smoke exposure Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels Epoxyeicosanoid signaling in CNS function and disease Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE₂ induced pain model Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive Altered behavioral phenotypes in soluble epoxide hydrolase knockout mice: effects of traumatic brain injury Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo Arachidonate Epoxygenase / Epoxide Hydrolase HPD: an online integrated human pathway database enabling systems biology studies.Hypoxia-induced pulmonary hypertension: comparison of soluble epoxide hydrolase deletion vs. inhibition.Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart.Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats.Mitochondrial P450-dependent arachidonic acid metabolism by TCDD-induced hepatic CYP1A5; conversion of EETs to DHETs by mitochondrial soluble epoxide hydrolase.Rationally designed multitarget agents against inflammation and pain.Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids.Epoxyeicosatrienoic acids are endogenous regulators of vasoactive neuropeptide release from trigeminal ganglion neurons Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication Temporal changes of cytochrome P450 (Cyp) and eicosanoid-related gene expression in the rat brain after traumatic brain injury.Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP.Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors.Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures.Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology.20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: photoaffinity labeling of a 14,15-epoxyeicosatrienoic acid receptor Effects of soluble epoxide hydrolase deficiency on acute pancreatitis in mice Soluble Epoxide Hydrolase Pharmacological Inhibition Ameliorates Experimental Acute Pancreatitis in Mice.

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Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs).

http://www.wikidata.org/entity/Q36681676

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J.PROSTAGLANDINS.2006.05.004

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Prostaglandins and Other Lipid Mediators

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Soluble epoxide hydrolase inhi ...... xyeicosatrienoic acids (EETs).

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Bora Inceoglu

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Bruce D Hammock

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Christophe Morisseau

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Kara R Schmelzer

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Steve L Jinks

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P2860

The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase

The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity

cDNA cloning and expression of a soluble epoxide hydrolase from human liver

Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis

Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS

Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase

Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation

Toxicity of epoxy fatty acids and related compounds to cells expressing human soluble epoxide hydrolase

Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function

Molecular mechanisms of nociception

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10.1016/J.PROSTAGLANDINS.2006.05.004

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1904338

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