Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)
about
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertilityHuman ALKBH7 is required for alkylation and oxidation-induced programmed necrosisRNA epigeneticsStructure and function of dioxygenases in histone demethylation and DNA/RNA demethylationTranscriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptationStructure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylationCrystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition.Structures of Human ALKBH5 Demethylase Reveal a Unique Binding Mode for Specific Single-stranded N 6 -Methyladenosine RNA DemethylationHuman ALKBH4 interacts with proteins associated with transcriptionNSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translationNovel AlkB dioxygenases--alternative models for in silico and in vivo studiesAdaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNASchizosaccharomyces pombe Ofd2 is a nuclear 2-oxoglutarate and iron dependent dioxygenase interacting with histonesHypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA.A rapid transcriptome response is associated with desiccation resistance in aerially-exposed killifish embryos.N6-methyl-adenosine (m6A) in RNA: an old modification with a novel epigenetic function.Alkbh8 Regulates Selenocysteine-Protein Expression to Protect against Reactive Oxygen Species Damage.The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond.Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts.Crystallization and preliminary X-ray diffraction of the RNA demethylase ALKBH5.Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells.Nucleic acid oxidation in DNA damage repair and epigeneticsDNA repair by reversal of DNA damage.Oxidative demethylation of DNA and RNA mediated by non-heme iron-dependent dioxygenases.Non-homologous functions of the AlkB homologs.m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program.The RNA Modification N6-methyladenosine and Its Implications in Human Disease.Epigenome-Wide Tumor DNA Methylation Profiling Identifies Novel Prognostic Biomarkers of Metastatic-Lethal Progression in Men Diagnosed with Clinically Localized Prostate Cancer.Sprouts of RNA epigenetics: the discovery of mammalian RNA demethylases.N-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progressionThe dual role of N6-methyladenosine modification of RNAs is involved in human cancersA Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5
P2860
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P2860
Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)
description
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2011年の論文
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name
Human AlkB homologue 5 is a nu ...... a-inducible factor 1α (HIF-1α)
@ast
Human AlkB homologue 5 is a nu ...... a-inducible factor 1α (HIF-1α)
@en
Human AlkB homologue 5 is a nu ...... a-inducible factor 1α (HIF-1α)
@en-gb
Human AlkB homologue 5 is a nu ...... a-inducible factor 1α (HIF-1α)
@nl
type
label
Human AlkB homologue 5 is a nu ...... a-inducible factor 1α (HIF-1α)
@ast
Human AlkB homologue 5 is a nu ...... a-inducible factor 1α (HIF-1α)
@en
Human AlkB homologue 5 is a nu ...... a-inducible factor 1α (HIF-1α)
@en-gb
Human AlkB homologue 5 is a nu ...... a-inducible factor 1α (HIF-1α)
@nl
prefLabel
Human AlkB homologue 5 is a nu ...... a-inducible factor 1α (HIF-1α)
@ast
Human AlkB homologue 5 is a nu ...... a-inducible factor 1α (HIF-1α)
@en
Human AlkB homologue 5 is a nu ...... a-inducible factor 1α (HIF-1α)
@en-gb
Human AlkB homologue 5 is a nu ...... a-inducible factor 1α (HIF-1α)
@nl
P2093
P2860
P50
P921
P3181
P1433
P1476
Human AlkB homologue 5 is a nu ...... a-inducible factor 1α (HIF-1α)
@en
P2093
Armin Thalhammer
David Mole
Ester M Hammond
Konstantinos Giaslakiotis
Linda O'Flaherty
Rachel Poole
Zuzana Bencokova
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0016210
P407
P50
P577
2011-01-01T00:00:00Z