about
Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2)PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylaseOGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formationHydroxylation of the eukaryotic ribosomal decoding center affects translational accuracyHuman AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylasesCrystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylaseStructural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factorStructural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase FamilyExpanding chemical biology of 2-oxoglutarate oxygenasesStructural studies on human 2-oxoglutarate dependent oxygenasesThe hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerensApplication of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.Evidence for a stereoelectronic effect in human oxygen sensing.Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humansStructure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylasesStructure and Mechanism of a Viral Collagen Prolyl HydroxylaseSudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth.Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases.Oxygenase catalyzed 5-methylcytosine hydroxylation.Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1alpha.2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases.YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase.Mutations to metabolic enzymes in cancer herald a need to unify genetics and biochemistry.Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study.Photoactivable peptides for identifying enzyme–substrate and protein–protein interactionsStudies on the Substrate Selectivity of the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Catalytic DomainOxygenases for oxygen sensingBorn to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animalSelective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal DecodingAn Oxygen Sensation: Progress in Macromolecule Hydroxylation Triggered by the Elucidation of Cellular Oxygen Sensing
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Christoph Loenarz
@ast
Christoph Loenarz
@en
Christoph Loenarz
@es
Christoph Loenarz
@nl
Christoph Loenarz
@sl
type
label
Christoph Loenarz
@ast
Christoph Loenarz
@en
Christoph Loenarz
@es
Christoph Loenarz
@nl
Christoph Loenarz
@sl
prefLabel
Christoph Loenarz
@ast
Christoph Loenarz
@en
Christoph Loenarz
@es
Christoph Loenarz
@nl
Christoph Loenarz
@sl
P108
P106
P1153
23479756200
P21
P31
P496
0000-0002-8843-2531