Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
about
Surprises in the 3'-end: 'U' can decide too!Proteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systemsHuman Mendelian diseases related to abnormalities of the RNA exosome or its cofactorsMicroRNA biogenesis pathways in cancerA critical switch in the enzymatic properties of the Cid1 protein deciphered from its product-bound crystal structureMechanisms of microRNA turnoverMechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathwaySingle-molecule pull-down for investigating protein-nucleic acid interactions.Alteration of miRNA activity via context-specific modifications of Argonaute proteins.Uridylation by TUT4 and TUT7 marks mRNA for degradation.Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2Regulation of pluripotency by RNA binding proteinsMonitoring the spatiotemporal activities of miRNAs in small animal models using molecular imaging modalities.RBM7 subunit of the NEXT complex binds U-rich sequences and targets 3'-end extended forms of snRNAsIdentification of small molecule inhibitors of Zcchc11 TUTase activity.TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms.A Single Let-7 MicroRNA Bypasses LIN28-Mediated Repression.The 3'-5' exoribonuclease Dis3 regulates the expression of specific microRNAs in Drosophila wing imaginal discs.Small RNAs meet their targets: when methylation defends miRNAs from uridylationDIS3 shapes the RNA polymerase II transcriptome in humans by degrading a variety of unwanted transcripts.Biogenesis and regulation of the let-7 miRNAs and their functional implications.Identification of factors involved in target RNA-directed microRNA degradation.Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAsTUT-DIS3L2 is a mammalian surveillance pathway for aberrant structured non-coding RNAsUridylation and adenylation of RNAs.Molecular basis for cytoplasmic RNA surveillance by uridylation-triggered decay in Drosophila.Perlman syndrome nuclease DIS3L2 controls cytoplasmic non-coding RNAs and provides surveillance pathway for maturing snRNAsA novel role for the 3'-5' exoribonuclease Dis3L2 in controlling cell proliferation and tissue growth.Attacked from All Sides: RNA Decay in Antiviral Defense.A common class of transcripts with 5'-intron depletion, distinct early coding sequence features, and N1-methyladenosine modification.Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively.Stepwise assembly of multiple Lin28 proteins on the terminal loop of let-7 miRNA precursors.The LIN28/let-7 Pathway in Cancer.Degradation of oligouridylated histone mRNAs: see UUUUU and goodbye.Dysregulation of microRNA biogenesis and gene silencing in cancer.Lin28: an emerging important oncogene connecting several aspects of cancer.A role of uridylation pathway for blockade of let-7 microRNA biogenesis by Lin28B.The epigenetic landscape of renal cancer.MotomiRs: miRNAs in Motor Neuron Function and Disease.Distinct 18S rRNA precursors are targets of the exosome complex, the exoribonuclease RRP6L2 and the terminal nucleotidyltransferase TRL in Arabidopsis thaliana.
P2860
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P2860
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
description
2013 nî lūn-bûn
@nan
2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
@ast
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
@en
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
@en-gb
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
@nl
type
label
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
@ast
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
@en
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
@en-gb
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
@nl
prefLabel
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
@ast
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
@en
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
@en-gb
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
@en
P2093
David Potesil
Dmytro Ustianenko
Dominika Hrossova
Jiri Pachernik
Katerina Cetkovska
Katerina Chalupnikova
Zbynek Zdrahal
P2860
P304
P3181
P356
10.1261/RNA.040055.113
P407
P577
2013-10-18T00:00:00Z