about
New insights into an X-traordinary viral proteinRegulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implicationsMechanisms of Allosteric Activation and Inhibition of the Deoxyribonucleoside Triphosphate Triphosphohydrolase from Enterococcus faecalisThe mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTPFunctional organization of human SAMHD1 and mechanisms of HIV-1 restrictionThe ribonuclease activity of SAMHD1 is required for HIV-1 restrictionGTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated stateEffects of human SAMHD1 polymorphisms on HIV-1 susceptibility.Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization.SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitorsMouse knockout models for HIV-1 restriction factors.dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.Structural basis of cellular dNTP regulation by SAMHD1.A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activitySubstrates and Inhibitors of SAMHD1.Structural basis of allosteric activation of sterile α motif and histidine-aspartate domain-containing protein 1 (SAMHD1) by nucleoside triphosphates.Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics.Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx.Structure of Escherichia coli dGTP triphosphohydrolase: a hexameric enzyme with DNA effector molecules.A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase.SAMHD1 specifically restricts retroviruses through its RNase activity.Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction.CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain.SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activityImpaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch.Structural Insights into the High-efficiency Catalytic Mechanism of the Sterile α-Motif/Histidine-Aspartate Domain-containing Protein.A continuous spectrophotometric enzyme-coupled assay for deoxynucleoside triphosphate triphosphohydrolasesLow dNTP levels are necessary but may not be sufficient for lentiviral restriction by SAMHD1.Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect.Deoxyribonucleotides as genetic and metabolic regulatorsSingle-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer.HIV suppression by host restriction factors and viral immune evasion.The druggability of intracellular nucleotide-degrading enzymes.A Putative Cyclin-binding Motif in Human SAMHD1 Contributes to Protein Phosphorylation, Localization, and Stability.A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse.Roles of SAMHD1 in antiviral defense, autoimmunity and cancer.Allosteric Activation of SAMHD1 Protein by Deoxynucleotide Triphosphate (dNTP)-dependent Tetramerization Requires dNTP Concentrations That Are Similar to dNTP Concentrations Observed in Cycling T Cells.SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.
P2860
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P2860
description
2013 nî lūn-bûn
@nan
2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Mechanism of allosteric activation of SAMHD1 by dGTP
@ast
Mechanism of allosteric activation of SAMHD1 by dGTP
@en
Mechanism of allosteric activation of SAMHD1 by dGTP
@en-gb
Mechanism of allosteric activation of SAMHD1 by dGTP
@nl
type
label
Mechanism of allosteric activation of SAMHD1 by dGTP
@ast
Mechanism of allosteric activation of SAMHD1 by dGTP
@en
Mechanism of allosteric activation of SAMHD1 by dGTP
@en-gb
Mechanism of allosteric activation of SAMHD1 by dGTP
@nl
prefLabel
Mechanism of allosteric activation of SAMHD1 by dGTP
@ast
Mechanism of allosteric activation of SAMHD1 by dGTP
@en
Mechanism of allosteric activation of SAMHD1 by dGTP
@en-gb
Mechanism of allosteric activation of SAMHD1 by dGTP
@nl
P2093
P2860
P921
P356
P1476
Mechanism of allosteric activation of SAMHD1 by dGTP
@en
P2093
Haitao Yang
Jacek Skowronski
Jennifer Mehrens
Jinwoo Ahn
Junpeng Yan
Maria DeLucia
Xiaoyun Ji
Yong Xiong
P2860
P2888
P304
P356
10.1038/NSMB.2692
P407
P577
2013-11-01T00:00:00Z
P5875
P6179
1019388861