The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
about
Restricting retrotransposons: a reviewSAMHD1 Limits HIV-1 Antigen Presentation by Monocyte-Derived Dendritic Cells.How SLX4 cuts through the mystery of HIV-1 Vpr-mediated cell cycle arrest.Functional organization of human SAMHD1 and mechanisms of HIV-1 restrictionAPOBEC3 Interference during Replication of Viral GenomesImmune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation during Chronic HIV-1 InfectionCyclin F/FBXO1 Interacts with HIV-1 Viral Infectivity Factor (Vif) and Restricts Progeny Virion Infectivity by Ubiquitination and Proteasomal Degradation of Vif Protein through SCFcyclin F E3 Ligase MachineryAicardi-Goutières syndrome and the type I interferonopathies.SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activitySubstrates and Inhibitors of SAMHD1.IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMPStructural basis of allosteric activation of sterile α motif and histidine-aspartate domain-containing protein 1 (SAMHD1) by nucleoside triphosphates.Cullin E3 ligases and their rewiring by viral factorsLow SAMHD1 expression following T-cell activation and proliferation renders CD4+ T cells susceptible to HIV-1.Select host restriction factors are associated with HIV persistence during antiretroviral therapy.Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx.A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase.Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers.High Expression of Antiviral Proteins in Mucosa from Individuals Exhibiting Resistance to Human Immunodeficiency VirusSAMHD1 specifically restricts retroviruses through its RNase activity.Complement-Opsonized HIV-1 Overcomes Restriction in Dendritic Cells.Vpx-Independent Lentiviral Transduction and shRNA-Mediated Protein Knock-Down in Monocyte-Derived Dendritic Cells.Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction.The Frequency of Cytidine Editing of Viral DNA Is Differentially Influenced by Vpx and Nucleosides during HIV-1 or SIVMAC Infection of Dendritic Cells.Central memory CD4+ T cells are preferential targets of double infection by HIV-1.ADAR1 Facilitates HIV-1 Replication in Primary CD4+ T CellsCyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain.SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activityCyclin D3-dependent control of the dNTP pool and HIV-1 replication in human macrophagesDifferential regulatory activities of viral protein X for anti-viral efficacy of nucleos(t)ide reverse transcriptase inhibitors in monocyte-derived macrophages and activated CD4(+) T cellsInhibition of HIV Expression and Integration in Macrophages by Methylglyoxal-Bis-Guanylhydrazone.Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach.Phosphorylation of murine SAMHD1 regulates its antiretroviral activityPhosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection.Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1Low dNTP levels are necessary but may not be sufficient for lentiviral restriction by SAMHD1.Cytosolic sulfotransferase 1A1 regulates HIV-1 minus-strand DNA elongation in primary human monocyte-derived macrophages.Vpx mediated degradation of SAMHD1 has only a very limited effect on lentiviral transduction rate in ex vivo cultured HSPCs.Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance
P2860
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P2860
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
description
2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2014
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im August 2014 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
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wetenschappelijk artikel (gepubliceerd op 2014/08/01)
@nl
наукова стаття, опублікована в серпні 2014
@uk
مقالة علمية (نشرت في أغسطس 2014)
@ar
name
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
@ast
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
@en
type
label
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
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The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
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prefLabel
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
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The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
@en
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P1476
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
@en
P2093
Changhoon Oh
Cheol-Heui Yun
Daehyun Baek
Daekwan Seo
Felipe Diaz-Griffero
Jeongmin Ryoo
Jongkyu Kim
Joseph A Hollenbaugh
Kwangseog Ahn
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P2888
P304
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10.1038/NM.3626
P407
P577
2014-07-20T00:00:00Z
P5875
P6179
1021735220