Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding
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Structure of glutaminyl cyclase fromDrosophila melanogasterin space groupI4Structural and functional analyses of a glutaminyl cyclase from Ixodes scapularis reveal metal-independent catalysis and inhibitor bindingSoluble variants of human recombinant glutaminyl cyclaseLinked production of pyroglutamate-modified proteins via self-cleavage of fusion tags with TEV protease and autonomous N-terminal cyclization with glutaminyl cyclase in vivoProbing secondary glutaminyl cyclase (QC) inhibitor interactions applying an in silico-modeling/site-directed mutagenesis approach: implications for drug development.The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.siRNA screen identifies QPCT as a druggable target for Huntington's disease.The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease.
P2860
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P2860
Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding
description
2011 nî lūn-bûn
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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
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name
Structures of human Golgi-resi ...... ovement upon inhibitor binding
@ast
Structures of human Golgi-resi ...... ovement upon inhibitor binding
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Structures of human Golgi-resi ...... ovement upon inhibitor binding
@en-gb
Structures of human Golgi-resi ...... ovement upon inhibitor binding
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type
label
Structures of human Golgi-resi ...... ovement upon inhibitor binding
@ast
Structures of human Golgi-resi ...... ovement upon inhibitor binding
@en
Structures of human Golgi-resi ...... ovement upon inhibitor binding
@en-gb
Structures of human Golgi-resi ...... ovement upon inhibitor binding
@nl
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Structures of Human Golgi-resi ...... ovement upon Inhibitor Binding
@en
prefLabel
Structures of human Golgi-resi ...... ovement upon inhibitor binding
@ast
Structures of human Golgi-resi ...... ovement upon inhibitor binding
@en
Structures of human Golgi-resi ...... ovement upon inhibitor binding
@en-gb
Structures of human Golgi-resi ...... ovement upon inhibitor binding
@nl
P2093
P2860
P921
P356
P1476
Structures of human Golgi-resi ...... ovement upon inhibitor binding
@en
P2093
Cho-Yun Chia
Kai-Fa Huang
Su-Sen Liaw
Wei-Lin Huang
Yan-Chung Lo
Yi-Ling Chen
P2860
P304
P356
10.1074/JBC.M110.208595
P407
P577
2011-04-08T00:00:00Z