siRNA screen identifies QPCT as a druggable target for Huntington's disease.
about
Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicityIdentification of potential glutaminyl cyclase inhibitors from lead-like libraries by in silico and in vitro fragment-based screening.A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases.Marine natural products with anti-inflammatory activity.Polyglutamine tracts regulate beclin 1-dependent autophagy.Huntington's Disease: Mechanisms of Pathogenesis and Therapeutic Strategies.Proteostasis of Huntingtin in Health and DiseaseCCT complex restricts neuropathogenic protein aggregation via autophagy.The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathwayDiscovery of Small Molecules that Induce the Degradation of Huntingtin.Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models.
P2860
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P2860
siRNA screen identifies QPCT as a druggable target for Huntington's disease.
description
2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年學術文章
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2015年學術文章
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2015年學術文章
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name
siRNA screen identifies QPCT as a druggable target for Huntington's disease.
@ast
siRNA screen identifies QPCT as a druggable target for Huntington's disease.
@en
type
label
siRNA screen identifies QPCT as a druggable target for Huntington's disease.
@ast
siRNA screen identifies QPCT as a druggable target for Huntington's disease.
@en
prefLabel
siRNA screen identifies QPCT as a druggable target for Huntington's disease.
@ast
siRNA screen identifies QPCT as a druggable target for Huntington's disease.
@en
P2093
P2860
P50
P921
P356
P1476
siRNA screen identifies QPCT as a druggable target for Huntington's disease.
@en
P2093
Alessia Tarditi
Andrea Caricasole
Arianna Nencini
Birte Sönnichsen
Cahir J O'Kane
Carla Scali
Chiara Caramelli
Daniela Diamanti
David C Rubinsztein
Eduardo Gonzalez-Couto
P2860
P2888
P304
P356
10.1038/NCHEMBIO.1790
P577
2015-04-06T00:00:00Z