Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines
about
TLR2 controls intestinal carcinogen detoxication by CYP1A1Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional studyInduction of P-450 in workers exposed to dioxinIdentification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptorInhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man.Biomarker measurements in a coastal fish-eating population environmentally exposed to organochlorines.Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicityVariations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamilyIntroduction of cytochrome P450IA2 metabolic capability into cell lines genetically matched for DNA repair proficiency/deficiencyBreast cancer risk and environmental exposuresMetabolism and biomarkers of heterocyclic aromatic amines in molecular epidemiology studies: lessons learned from aromatic aminesDetermination of P4501A2 activity in human liver microsomes using [3-14C-methyl]caffeineRegulatory mechanisms in the activation of nitrogenous compounds by mammalian cytochrome P-450 isozymes.Contributions of human enzymes in carcinogen metabolismHuman response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR.Summary of information on human CYP enzymes: human P450 metabolism data.Interaction of smoking, uptake of polycyclic aromatic hydrocarbons, and cytochrome P450IA2 activity among foundry workers.DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis.Effect of diet and nutrition on the expression of cytochromes P450.Role of N-acetyltransferase polymorphisms in hepatitis B related hepatocellular carcinoma: impact of smoking on risk.Molecular mechanisms and pathways in bladder cancer development and progression.Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.Identification of carcinogen DNA adducts in human saliva by linear quadrupole ion trap/multistage tandem mass spectrometry.Polymorphisms of caffeine metabolism and estrogen receptor genes and risk of Parkinson's disease in men and women.Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline.Single nucleotide polymorphisms, metabolic activation and environmental carcinogenesis: why molecular epidemiologists should think about enzyme expression.Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults.Inhibition of caffeine metabolism by ciprofloxacin in children with cystic fibrosis as measured by the caffeine breath testCaffeine as a metabolic probe: a comparison of the metabolic ratios used to assess CYP1A2 activity.Environmental tobacco smoke in relation to bladder cancer risk--the Shanghai bladder cancer study [corrected].Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors.Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate.Caffeine accelerates absorption and enhances the analgesic effect of acetaminophen.N-oxidative transformation of free and N-substituted amine functions by cytochrome P450 as means of bioactivation and detoxication.N-hydroxyarylamines.Advances in mechanisms of activation and deactivation of environmental chemicalsImmunohistochemical detection of pulmonary cytochrome P450IA and metabolic activities associated with P450IA1 and P450IA2 isozymes in lung cancer patientsPolymorphisms for aromatic amine metabolism in humans: relevance for human carcinogenesisUrinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone).Rate-limiting steps in cytochrome P450 catalysis.
P2860
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P2860
Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines
description
1989 nî lūn-bûn
@nan
1989 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Human cytochrome P-450PA (P-45 ...... ion of carcinogenic arylamines
@ast
Human cytochrome P-450PA (P-45 ...... ion of carcinogenic arylamines
@en
Human cytochrome P-450PA (P-45 ...... ion of carcinogenic arylamines
@en-gb
Human cytochrome P-450PA (P-45 ...... ion of carcinogenic arylamines
@nl
type
label
Human cytochrome P-450PA (P-45 ...... ion of carcinogenic arylamines
@ast
Human cytochrome P-450PA (P-45 ...... ion of carcinogenic arylamines
@en
Human cytochrome P-450PA (P-45 ...... ion of carcinogenic arylamines
@en-gb
Human cytochrome P-450PA (P-45 ...... ion of carcinogenic arylamines
@nl
prefLabel
Human cytochrome P-450PA (P-45 ...... ion of carcinogenic arylamines
@ast
Human cytochrome P-450PA (P-45 ...... ion of carcinogenic arylamines
@en
Human cytochrome P-450PA (P-45 ...... ion of carcinogenic arylamines
@en-gb
Human cytochrome P-450PA (P-45 ...... ion of carcinogenic arylamines
@nl
P2093
P2860
P3181
P356
P1476
Human cytochrome P-450PA (P-45 ...... ion of carcinogenic arylamines
@en
P2093
F F Kadlubar
F P Guengerich
M A Butler
P2860
P304
P3181
P356
10.1073/PNAS.86.20.7696
P407
P577
1989-10-01T00:00:00Z