A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration - Wikidata - wikimedia - TriplyDB

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

http://www.wikidata.org/entity/Q24523983

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CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD Interpretation of genetic association studies: markers with replicated highly significant odds ratios may be poor classifiers Structural effects of fibulin 5 missense mutations associated with age-related macular degeneration and cutis laxa Complement inhibitors for age-related macular degeneration Complement inhibitors for age-related macular degeneration Drusen complement components C3a and C5a promote choroidal neovascularization Bivalent and co-operative binding of complement factor H to heparan sulfate and heparin Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA Susceptibility genes for age-related maculopathy on chromosome 10q26.Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration Sublytic membrane-attack-complex (MAC) activation alters regulated rather than constitutive vascular endothelial growth factor (VEGF) secretion in retinal pigment epithelium monolayers Variation near complement factor I is associated with risk of advanced AMD The expression of advanced glycation endproduct receptors in rpe cells associated with basal deposits in human maculas Structural basis for engagement by complement factor H of C3b on a self surface Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)Therapeutic targets in age-related macular disease A longitudinal follow-up study of saffron supplementation in early age-related macular degeneration: sustained benefits to central retinal function Complement in age-related macular degeneration: a focus on function Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module Structure of complement fragment C3b-factor H and implications for host protection by complement regulators Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease)Complement factor H and the hemolytic uremic syndrome Structural basis for complement factor H linked age-related macular degeneration The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD The genetics of schizophrenia Genetics and age-related macular degeneration: a practical review for the clinician Cellular and Molecular Pathology of Age-Related Macular Degeneration: Potential Role for Proteoglycans Amyloidosis in Retinal Neurodegenerative Diseases AMD and the alternative complement pathway: genetics and functional implications Regulation of signaling events involved in the pathophysiology of neovascular AMD Inflammation and its role in age-related macular degeneration Fucoidan as a Potential Therapeutic for Major Blinding Diseases--A Hypothesis Dementia of the eye: the role of amyloid beta in retinal degeneration Genetics of immunological and inflammatory components in age-related macular degeneration

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P2860

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

http://www.wikidata.org/entity/Q24523983

description

2005 nî lūn-bûn

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2005 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2005 թվականի մայիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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A common haplotype in the comp ...... e-related macular degeneration

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A common haplotype in the comp ...... e-related macular degeneration

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Proceedings of the National Academy of Sciences of the United States of America

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Adam K Olsh

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Andrew J Taiber

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Bert Gold

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Don H Anderson

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Gaetano R Barile

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Giuliana Silvestri

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Gregory S Hageman

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Heather A Stockman

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Irene Barbazetto

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James D Borchardt

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P2860

Inflammation and Alzheimer's disease

An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration

Visual impairment caused by retinal abnormalities in mesangiocapillary (membranoproliferative) glomerulonephritis type II ("dense deposit disease")

Linkage of a gene causing familial membranoproliferative glomerulonephritis type III to chromosome 1

Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration

The human complement factor H: functional roles, genetic variations and disease associations

Missense variations in the fibulin 5 gene and age-related macular degeneration

Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration

Macrophage depletion diminishes lesion size and severity in experimental choroidal neovascularization.

A cell culture medium that supports the differentiation of human retinal pigment epithelium into functionally polarized monolayers.

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75122

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10.1073/PNAS.0501536102

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20

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102

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Stephen R Russell

Caroline C Klaver

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7868608

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