AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization.
about
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1Dual inhibitory effects of APOBEC family proteins on retrotransposition of mammalian endogenous retrovirusesEtoposide induces nuclear re-localisation of AIDFirst AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodiesThe interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombinationTemporal regulation of Ig gene diversification revealed by single-cell imaging.Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization.Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase.Functions and regulation of the APOBEC family of proteinsGANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA.Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.AID and somatic hypermutation.Evidence for APOBEC3B mutagenesis in multiple human cancersActivation-induced cytidine deaminase alters the subcellular localization of Tet family proteins.LINE-1 retroelements complexed and inhibited by activation induced cytidine deaminase.Targeting of somatic hypermutation.Regulation of hypermutation by activation-induced cytidine deaminase phosphorylationRole of activation-induced cytidine deaminase in the development of oral squamous cell carcinomaAID and mismatch repair in antibody diversification.Generation and characterization of induced pluripotent stem cells from Aid-deficient mice.What role for AID: mutator, or assembler of the immunoglobulin mutasome?Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm.Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A).The boundaries of the distribution of somatic hypermutation of rearranged immunoglobulin variable genes.Cell Cycle Regulates Nuclear Stability of AID and Determines the Cellular Response to AID.On the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes.Mice lacking Sμ tandem repeats maintain RNA polymerase patterns but exhibit histone modification pattern shifts linked to class switch site locations.DNA deamination in immunity.Mechanisms of Yin Yang 1 in oncogenesis: the importance of indirect effects.AID to overcome the limitations of genomic information.Activation-Induced Cytidine Deaminase Expression in Human B Cell Precursors Is Essential for Central B Cell Tolerance.A role for the RNA pol II-associated PAF complex in AID-induced immune diversificationEvaluation of molecular models for the affinity maturation of antibodies: roles of cytosine deamination by AID and DNA repairSomatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase.Proteasomal degradation restricts the nuclear lifespan of AIDAID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development.AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunityThe stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence.Restricting activation-induced cytidine deaminase tumorigenic activity in B lymphocytes.
P2860
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P2860
AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
AID-GFP chimeric protein incre ...... idence of nuclear localization
@nl
AID-GFP chimeric protein incre ...... dence of nuclear localization.
@ast
AID-GFP chimeric protein incre ...... dence of nuclear localization.
@en
AID-GFP chimeric protein incre ...... dence of nuclear localization.
@en-gb
type
label
AID-GFP chimeric protein incre ...... idence of nuclear localization
@nl
AID-GFP chimeric protein incre ...... dence of nuclear localization.
@ast
AID-GFP chimeric protein incre ...... dence of nuclear localization.
@en
AID-GFP chimeric protein incre ...... dence of nuclear localization.
@en-gb
prefLabel
AID-GFP chimeric protein incre ...... idence of nuclear localization
@nl
AID-GFP chimeric protein incre ...... dence of nuclear localization.
@ast
AID-GFP chimeric protein incre ...... dence of nuclear localization.
@en
AID-GFP chimeric protein incre ...... dence of nuclear localization.
@en-gb
P2093
P2860
P356
P1476
AID-GFP chimeric protein incre ...... dence of nuclear localization.
@en
P2093
Cristina Rada
César Milstein
John M Jarvis
P2860
P304
P356
10.1073/PNAS.092160999
P407
P577
2002-05-01T00:00:00Z