Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2

Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2

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http://www.wikidata.org/entity/Q24535664

Q24535664

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Implications of the serine protease HtrA1 in amyloid precursor protein processing Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3 Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer Distribution of the serine protease HtrA1 in normal human tissues The role of human HtrA1 in arthritic disease Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains HtrA3 as an early marker for preeclampsia: specific monoclonal antibodies and sensitive high-throughput assays for serum screening.Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening.Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood.Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities.Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease.High-temperature-required protein A2 as a predictive marker for response to chemotherapy and prognosis in patients with high-grade serous ovarian cancers.Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice.Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome OASIS/CREB3L1 is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration in vitro High temperature requirement A1, transforming growth factor beta1, phosphoSmad2 and Ki67 in eutopic and ectopic endometrium of women with endometriosis.HtrA3 Is Downregulated in Cancer Cell Lines and Significantly Reduced in Primary Serous and Granulosa Cell Ovarian Tumors.HTRA3 expression in non-pregnant rhesus monkey ovary and endometrium, and at the maternal-fetal interface during early pregnancy Prediction of preeclampsia - a workshop report High levels of HtrA4 observed in preeclamptic circulation drastically alter endothelial gene expression and induce inflammation in human umbilical vein endothelial cells.High temperature requirement A3 (HTRA3) expression predicts postoperative recurrence and survival in patients with non-small-cell lung cancer.HtrA serine proteases as potential therapeutic targets in cancer.Radiation-inducible HtrA2 gene enhances radiosensitivity of uveal melanoma OCM-1 cells in vitro and in vivo.HtrA3 is negatively correlated with lymph node metastasis in invasive ductal breast cancer.High temperature requirement A3 (HtrA3) promotes etoposide- and cisplatin-induced cytotoxicity in lung cancer cell lines Autocatalytic processing of HtrA2/Omi is essential for induction of caspase-dependent cell death through antagonizing XIAP.Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression.Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1.The serine protease HtrA1 is upregulated in the human placenta during pregnancy.Changes in the level of serum high-temperature requirement A1 (HtrA1) during pregnancy and its relationship to preeclampsia.Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells.Pattern of expression of HtrA1 during mouse development.Decidual HtrA3 negatively regulates trophoblast invasion during human placentation.The expression of HtrA2 and its diagnostic value in patients with hepatocellular carcinoma.The protease inhibitor Ucf-101 induces cellular responses independently of its known target, HtrA2/Omi

P2860

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P2860

Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2

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http://www.wikidata.org/entity/Q24535664

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