Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice. - Wikidata - wikimedia - TriplyDB

Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice.

Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice.

http://www.wikidata.org/entity/Q35197893

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Polypoidal Choroidal Vasculopathy in Asians Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes Inhibition of cell proliferation, migration and apoptosis in blue-light illuminated human retinal pigment epithelium cells by down-regulation of HtrA1.Spontaneous CNV in a novel mutant mouse is associated with early VEGF-A-driven angiogenesis and late-stage focal edema, neural cell loss, and dysfunction.The autolysis of human HtrA1 is governed by the redox state of its N-terminal domain Variants at chromosome 10q26 locus and the expression of HTRA1 in the retina.The Y141C knockin mutation in RDS leads to complex phenotypes in the mouse.Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration.Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling Association of rs6982567 near GDF6 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in a Han Chinese cohort.Translational models of ocular disease.HTRA1 (high temperature requirement A serine peptidase 1) gene is transcriptionally regulated by insertion/deletion nucleotides located at the 3' end of the ARMS2 (age-related maculopathy susceptibility 2) gene in patients with age-related macular d Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy.Detecting abnormalities in choroidal vasculature in a mouse model of age-related macular degeneration by time-course indocyanine green angiography Genetic deletion of S-opsin prevents rapid cone degeneration in a mouse model of Leber congenital amaurosis High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6.Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degeneration Genetic associations in polypoidal choroidal vasculopathy: a systematic review and meta-analysis Evidence of Alternative Cystatin C Signal Sequence Cleavage Which Is Influenced by the A25T Polymorphism.Epigenetic silencing of serine protease HTRA1 drives polyploidy.Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epithelium Evidence of a novel gene HERPUD1 in polypoidal choroidal vasculopathy.Serum levels of matrix metalloproteinase 2 and matrix metalloproteinase 9 elevated in polypoidal choroidal vasculopathy but not in age-related macular degeneration Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1.Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology.Mechanisms of age-related macular degeneration and therapeutic opportunities.HtrA1 is a novel antagonist controlling fibroblast growth factor (FGF) signaling via cleavage of FGF8.Role of HTRA1 in bone formation and regeneration: In vitro and in vivo evaluation.Protective effects of an HTRA1 insertion-deletion variant against age-related macular degeneration in the Chinese populations.Inhibition of cell proliferation and migration after HTRA1 knockdown in retinal pigment epithelial cells.Overexpression of HTRA1 leads to down-regulation of fibronectin and functional changes in RF/6A cells and HUVECs.Determinants of amyloid fibril degradation by the PDZ protease HTRA1.Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.HTRA1 promoter variant differentiates polypoidal choroidal vasculopathy from exudative age-related macular degeneration.A functional approach to examine the role of HTRA1 versus ARMS2 in AMD.Lipopolysaccharide increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA-1 expression.Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations.ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity.HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model.

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P2860

Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice.

http://www.wikidata.org/entity/Q35197893

description

2011 nî lūn-bûn

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2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2011 թվականի օգոստոսին հրատարակված գիտական հոդված

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Proceedings of the National Academy of Sciences of the United States of America

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Increased expression of multif ...... horoidal vasculopathy in mice.

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Amrita

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Balamurali Ambati

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Ling Luo

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P2860

Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA

Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2

A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration

Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3

HTRA1 promoter polymorphism in wet age-related macular degeneration

The HtrA Family of Proteases

The origins of polypoidal choroidal vasculopathy

Serum elastin-derived peptides in age-related macular degeneration.

Analysis of the indel at the ARMS2 3'UTR in age-related macular degeneration.

Polypoidal choroidal vasculopathy: an angiographic discussion.

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