Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice.
about
Polypoidal Choroidal Vasculopathy in AsiansProtoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine proteaseHeritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypesInhibition of cell proliferation, migration and apoptosis in blue-light illuminated human retinal pigment epithelium cells by down-regulation of HtrA1.Spontaneous CNV in a novel mutant mouse is associated with early VEGF-A-driven angiogenesis and late-stage focal edema, neural cell loss, and dysfunction.The autolysis of human HtrA1 is governed by the redox state of its N-terminal domainVariants at chromosome 10q26 locus and the expression of HTRA1 in the retina.The Y141C knockin mutation in RDS leads to complex phenotypes in the mouse.Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration.Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signalingAssociation of rs6982567 near GDF6 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in a Han Chinese cohort.Translational models of ocular disease.HTRA1 (high temperature requirement A serine peptidase 1) gene is transcriptionally regulated by insertion/deletion nucleotides located at the 3' end of the ARMS2 (age-related maculopathy susceptibility 2) gene in patients with age-related macular dComplement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy.Detecting abnormalities in choroidal vasculature in a mouse model of age-related macular degeneration by time-course indocyanine green angiographyGenetic deletion of S-opsin prevents rapid cone degeneration in a mouse model of Leber congenital amaurosisHigh temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6.Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degenerationGenetic associations in polypoidal choroidal vasculopathy: a systematic review and meta-analysisEvidence of Alternative Cystatin C Signal Sequence Cleavage Which Is Influenced by the A25T Polymorphism.Epigenetic silencing of serine protease HTRA1 drives polyploidy.Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epitheliumEvidence of a novel gene HERPUD1 in polypoidal choroidal vasculopathy.Serum levels of matrix metalloproteinase 2 and matrix metalloproteinase 9 elevated in polypoidal choroidal vasculopathy but not in age-related macular degenerationAge-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1.Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology.Mechanisms of age-related macular degeneration and therapeutic opportunities.HtrA1 is a novel antagonist controlling fibroblast growth factor (FGF) signaling via cleavage of FGF8.Role of HTRA1 in bone formation and regeneration: In vitro and in vivo evaluation.Protective effects of an HTRA1 insertion-deletion variant against age-related macular degeneration in the Chinese populations.Inhibition of cell proliferation and migration after HTRA1 knockdown in retinal pigment epithelial cells.Overexpression of HTRA1 leads to down-regulation of fibronectin and functional changes in RF/6A cells and HUVECs.Determinants of amyloid fibril degradation by the PDZ protease HTRA1.Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.HTRA1 promoter variant differentiates polypoidal choroidal vasculopathy from exudative age-related macular degeneration.A functional approach to examine the role of HTRA1 versus ARMS2 in AMD.Lipopolysaccharide increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA-1 expression.Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations.ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity.HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model.
P2860
Q26799548-AB0BEF40-CA25-43E4-B626-680E537A7BB1Q28542717-F004CD64-5C6E-46EA-A9A4-DA870292D974Q28943546-A57C40A5-61E7-46DE-9F7D-3B667E34857AQ33607722-0AD20FF3-6109-4BF3-B5C9-77ABBF8A2296Q33761013-B14F52D1-7F50-4B10-910F-1F58D0E6EC36Q33792759-469764E7-89FE-4149-AB33-7E9D91115D49Q33803810-D41DD631-6CDD-47A6-8CD9-3A969C1CAE6CQ34463210-ADD9F386-E855-4B53-97EF-BA2800C05153Q34518507-2F46CA9F-A039-4428-90C0-FED9657E0568Q34581220-AFD2925A-5A89-4351-A32C-F1486FF2E1BDQ34610204-9308A23F-1BD0-40D1-B9EF-2B35D4B5ABCBQ34764453-DDBE1038-AC27-4627-B252-869A6E71F422Q35048990-6AF84FA1-5DE7-426A-9E71-C464597AB371Q35118257-5228BDAB-74A7-4CC4-BB70-7072F07AFFC3Q35122718-136082AA-F4B2-45CB-A181-8046D19B7E4BQ35152826-446E24AC-72A4-41C4-BE9E-451E6CB838C2Q35668755-6C7553D4-D4AC-47A3-94E4-B77F1353B8DAQ35819298-911658C4-ABC5-4E78-B1DE-421E27BC368EQ35883348-0BC843C7-324E-45A8-9835-D786968701ABQ35914308-BB26138F-70B4-4CB7-ADDB-E7DC7814003CQ36070152-8D50CB25-E936-4794-87CE-94DBA8D9C52AQ36089419-81547AF6-937A-4738-9153-8B62E23A2E47Q36464296-DFB14045-1A0C-4AE1-9DE1-CA16A4B89F42Q36727683-5D5833D8-E124-4EC7-BBC2-D6F77E4D078BQ36826856-16C5008B-598B-42F0-ABB1-44ABD06E34BEQ37256088-BB8171B1-62FC-40B9-85B2-C73D16FE27CEQ38150757-FEDA1E39-30E6-414A-8912-A579B01352DFQ38458788-B2C41CF8-F7B5-487C-80C7-5EF4BE893CA2Q38696646-F6DFC531-5949-46DD-8FD6-4B5D3E2B8C98Q38731149-2CCEE48B-D4F5-4ADD-A121-12D927416C21Q38924357-1B2D544B-6181-49FE-9787-37EA27DD180DQ39261579-FA630E02-3026-4E19-BAA6-529EE86C905FQ42152333-8529D1D8-7FE5-4C57-8105-9492666164D6Q42201998-6235D4BD-B188-41FC-85FF-318B6A436121Q42545847-5425670F-EEA3-486C-B5E7-B5479FFF8328Q43242521-16A0CDC8-6ED2-4B73-942C-759ECBB0BF20Q44389872-894212A1-FA43-4122-B580-F068B35D542AQ46716950-93A07508-26A0-4743-A033-DACCE1E43111Q47189539-8A371CDE-35BE-4353-BCA6-5C7C4FFD7463Q47263577-99C8C921-CC18-470D-8149-55FD83A395EF
P2860
Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice.
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Increased expression of multif ...... horoidal vasculopathy in mice.
@ast
Increased expression of multif ...... horoidal vasculopathy in mice.
@en
type
label
Increased expression of multif ...... horoidal vasculopathy in mice.
@ast
Increased expression of multif ...... horoidal vasculopathy in mice.
@en
prefLabel
Increased expression of multif ...... horoidal vasculopathy in mice.
@ast
Increased expression of multif ...... horoidal vasculopathy in mice.
@en
P2093
P2860
P356
P1476
Increased expression of multif ...... horoidal vasculopathy in mice.
@en
P2093
Alex Jones
Balamurali Ambati
Heather Fillerup
James Anderson
Jia-Hui Yang
Kang Zhang
P2860
P304
14578-14583
P356
10.1073/PNAS.1102853108
P407
P577
2011-08-15T00:00:00Z