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Somatic hypermutation of the AID transgene in B and non-B cells

Somatic hypermutation of the AID transgene in B and non-B cells

http://www.wikidata.org/entity/Q24535846

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Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1 The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1 Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate Hepatitis C Virus (HCV)-Induced Immunoglobulin Hypermutation Reduces the Affinity and Neutralizing Activities of Antibodies against HCV Envelope Protein AID targeting is dependent on RNA polymerase II pausing.Isotype-switched follicular lymphoma displays dissociation between activation-induced cytidine deaminase expression and somatic hypermutation AID targeting: old mysteries and new challenges AID and Apobec3G haphazard deamination and mutational diversity Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.A coming-of-age story: activation-induced cytidine deaminase turns 10.The BRCT domain of PARP-1 is required for immunoglobulin gene conversion.Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies Activation-induced deaminase cloning, localization, and protein extraction from young VH-mutant rabbit appendix.Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis.Peripheral B cells latently infected with Epstein-Barr virus display molecular hallmarks of classical antigen-selected memory B cells.Negative regulation of activation-induced cytidine deaminase in B cells Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Class-switch recombination: after the dawn of AID.What role for AID: mutator, or assembler of the immunoglobulin mutasome?Recombinase-mediated cassette exchange as a novel method to study somatic hypermutation in Ramos cells Novel molecular diagnostic and therapeutic targets in chronic lymphocytic leukaemia.UNG shapes the specificity of AID-induced somatic hypermutation.AID to overcome the limitations of genomic information.Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences.A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells Proteasomal degradation restricts the nuclear lifespan of AID Increased IL-12 inhibits B cells' differentiation to germinal center cells and promotes differentiation to short-lived plasmablasts.The origin of recurrent translocations in recombining lymphocytes: a balance between break frequency and nuclear proximity.Forced expression of AID facilitates the isolation of class switch variants from hybridoma cells.AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination.AID: a riddle wrapped in a mystery inside an enigma.The role of somatic hypermutation in the generation of pathogenic antibodies in SLE.AID and APOBEC deaminases: balancing DNA damage in epigenetics and immunity.Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney Downregulation of the B-cell receptor signaling component CD79b in plasma cell myeloma: a possible post transcriptional regulation.

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Somatic hypermutation of the AID transgene in B and non-B cells

http://www.wikidata.org/entity/Q24535846

description

2002 nî lūn-bûn

@nan

2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2002年の論文

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2002年論文

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2002年論文

@zh-hant

2002年論文

@zh-hk

2002年論文

@zh-mo

2002年論文

@zh-tw

2002年论文

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name

Somatic hypermutation of the AID transgene in B and non-B cells

@ast

Somatic hypermutation of the AID transgene in B and non-B cells

@en

Somatic hypermutation of the AID transgene in B and non-B cells

@nl

type

label

Somatic hypermutation of the AID transgene in B and non-B cells

@ast

Somatic hypermutation of the AID transgene in B and non-B cells

@en

Somatic hypermutation of the AID transgene in B and non-B cells

@nl

prefLabel

Somatic hypermutation of the AID transgene in B and non-B cells

@ast

Somatic hypermutation of the AID transgene in B and non-B cells

@en

Somatic hypermutation of the AID transgene in B and non-B cells

@nl

P1433

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P1433

Proceedings of the National Academy of Sciences of the United States of America

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Somatic hypermutation of the AID transgene in B and non-B cells

@en

P2093

Alberto Martin

http://www.w3.org/2001/XMLSchema#string

Matthew D Scharff

http://www.w3.org/2001/XMLSchema#string

P2860

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

Patterns of somatic mutations in immunoglobulin variable genes

APOLIPOPROTEIN B: mRNA editing, lipoprotein assembly, and presecretory degradation.

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12304-12308

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scholarly article

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10.1073/PNAS.192442899

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19

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99

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2002-08-29T00:00:00Z

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11185360

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P698

12202747

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129440

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