Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate - Wikidata - wikimedia - TriplyDB

Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate

Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate

http://www.wikidata.org/entity/Q24802780

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Positive Cofactor 4 (PC4) is critical for DNA repair pathway re-routing in DT40 cells Temporal regulation of Ig gene diversification revealed by single-cell imaging.A role for PCNA ubiquitination in immunoglobulin hypermutation.DNA-dependent protein kinase inhibits AID-induced antibody gene conversion.Chromatin structure regulates gene conversion.A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation.RAD51 paralogs promote homology-directed repair at diversifying immunoglobulin V regions Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination.Attracting AID to targets of somatic hypermutation.Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) protein Classical Mus musculus Igκ enhancers support transcription but not high level somatic hypermutation from a V-lambda promoter in chicken DT40 cells.Lysine residue at position 22 of the AID protein regulates its class switch activity.The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombination Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90.Involvement of Rad18 in somatic hypermutation Exceptionally long CDR3H are not isotype restricted in bovine immunoglobulins.Targeting of AID-mediated sequence diversification to immunoglobulin genes Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.Usefulness of a Darwinian system in a biotechnological application: evolution of optical window fluorescent protein variants under selective pressure.Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm.Topoisomerase I deficiency causes RNA polymerase II accumulation and increases AID abundance in immunoglobulin variable genes Directed evolution of human scFvs in DT40 cells.DNA deamination in immunity.Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences.Protein evolution by hypermutation and selection in the B cell line DT40 AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene.Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions Avian model for B-cell immunology--new genomes and phylotranscriptomics.Non-conservative homologous recombination in human B lymphocytes is promoted by activation-induced cytidine deaminase and transcription.Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence.Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line.Timing matters: error-prone gap filling and translesion synthesis in immunoglobulin gene hypermutation Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination Technologies of directed protein evolution in vivo.Genetic diversification by somatic gene conversion.Checkpoint kinase 1 negatively regulates somatic hypermutation.A double-strand break can trigger immunoglobulin gene conversion The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas.RNA binding to APOBEC deaminases; Not simply a substrate for C to U editing.

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Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate

http://www.wikidata.org/entity/Q24802780

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2004 nî lūn-bûn

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2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2004 թվականի հուլիսին հրատարակված գիտական հոդված

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2004年の論文

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JOURNAL.PBIO.0020179

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Hiroshi Arakawa

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Huseyin Saribasak

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Jean-Marie Buerstedde

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P2860

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

Somatic hypermutation of the AID transgene in B and non-B cells

Mutant loxP vectors for selectable marker recycle and conditional knock-outs

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

An immunoglobulin mutator that targets G.C base pairs.

Light chain gene conversion continues at high rate in an ALV-induced cell line.

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

Mating-type gene switching in Saccharomyces cerevisiae.

Immunoglobulin gene conversion: insights from bursal B cells and the DT40 cell line.

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10.1371/JOURNAL.PBIO.0020179

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15252444

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449846

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