GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
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Neutrophil apoptosis mediated by nicotinic acid receptors (GPR109A)Flushing out the role of GPR109A (HM74A) in the clinical efficacy of nicotinic acidRegulation of hepatic ApoC3 expression by PGC-1β mediates hypolipidemic effect of nicotinic acidNicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in micebeta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in miceEmerging preclinical pharmacological targets for Parkinson's diseaseMultifaceted role of β-arrestins in inflammation and diseaseTargeting sirtuin 1 to improve metabolism: all you need is NAD(+)?NAD+ as a signaling molecule modulating metabolismNiacin, an old drug with a new twistNicotinic acid receptor agonists differentially activate downstream effectorsTranslating the basic knowledge of mitochondrial functions to metabolic therapy: role of L-carnitineNiacin sensitivity and the arachidonic acid pathway in schizophreniaNiacin in pharmacological doses alters microRNA expression in skeletal muscle of obese Zucker rats.A "hot" topic in dyslipidemia management--"how to beat a flush": optimizing niacin tolerability to promote long-term treatment adherence and coronary disease prevention.Nicotinic acid activates the capsaicin receptor TRPV1: Potential mechanism for cutaneous flushing.Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation.Internalization of the human nicotinic acid receptor GPR109A is regulated by G(i), GRK2, and arrestin3.Seeing red: flushing out instigators of niacin-associated skin toxicity.Synthesis and in vitro evaluation of potential sustained release prodrugs via targeting ASBTFuture of GPR109A agonists in the treatment of dyslipidaemia.Niacin: the evidence, clinical use, and future directions.Role of prostaglandin D2 and the autonomic nervous system in niacin-induced flushing.Nicotinic acid modulates intracellular calcium concentration and disassembles the cytoskeleton.Inflammation stimulates niacin receptor (GPR109A/HCA2) expression in adipose tissue and macrophages.The flavonoid luteolin inhibits niacin-induced flushAntagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans.Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans.Extended release niacin-laropiprant in patients with hypercholesterolemia or mixed dyslipidemias improves clinical parametersHigh dietary niacin may increase prostaglandin formation but does not increase tumor formation in ApcMin/+ mice.Niacin inhibits skin dendritic cell mobilization in a GPR109A independent manner but has no impact on monocyte trafficking in atherosclerosis.NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the NucleusFumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS.Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes.Biological roles and therapeutic potential of hydroxy-carboxylic Acid receptors.1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway.Activated human hydroxy-carboxylic acid receptor-3 signals to MAP kinase cascades via the PLC-dependent PKC and MMP-mediated EGFR pathways.A randomized pilot study on the effect of niacin on pulmonary arterial pressure.Aspirin in dermatology: Revisited.Identification and characterization of distinct C-terminal domains of the human hydroxycarboxylic acid receptor-2 that are essential for receptor export, constitutive activity, desensitization, and internalization.
P2860
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P2860
GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
@ast
GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
@en
GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
@nl
type
label
GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
@ast
GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
@en
GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
@nl
prefLabel
GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
@ast
GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
@en
GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
@nl
P2093
P2860
P50
P3181
P356
P1476
GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
@en
P2093
Alexandra Moers
Marie Catherine Suchánková
Marion Csiky
Rolf M Nüsing
P2860
P304
P3181
P356
10.1172/JCI23626
P407
P577
2005-12-01T00:00:00Z