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Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration

Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration

http://www.wikidata.org/entity/Q24536348

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FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes ApoE promotes the proteolytic degradation of Abeta Oxidized cholesterol as the driving force behind the development of Alzheimer's disease Role of Nuclear Receptors in Central Nervous System Development and Associated Diseases Structure of the retinoid X receptor α-liver X receptor β (RXRα-LXRβ) heterodimer on DNA Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice Nuclear Receptor NR1H3 in Familial Multiple Sclerosis Lipid pathway alterations in Parkinson's disease primary visual cortex Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols Liver X receptors regulate cholesterol homeostasis in oligodendrocytes Anxiety in liver X receptor β knockout female mice with loss of glutamic acid decarboxylase in ventromedial prefrontal cortex.Atypical parkinsonism and cerebrotendinous xanthomatosis: report of a family with corticobasal syndrome and a literature review.Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle Proteomic profiling of human intraschisis cavity fluid Cholesterol in the Pathogenesis of Alzheimer's, Parkinson's Diseases and Autism: Link to Synaptic Dysfunction Minireview: liver X receptor beta: emerging roles in physiology and diseases.Abnormal gene expression in cerebellum of Npc1-/- mice during postnatal development.Isoprenoids, small GTPases and Alzheimer's disease.Liver X receptor beta and thyroid hormone receptor alpha in brain cortical layering.Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis?Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration.Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration.Nuclear receptors in neurodegenerative diseases.Cholesterol in brain disease: sometimes determinant and frequently implicated.Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors Central nervous system: cholesterol turnover, brain development and neurodegeneration.Targeting cholesterol homeostasis to fight hearing loss: a new perspective.Cholestenoic acids regulate motor neuron survival via liver X receptors.Nuclear receptors as therapeutic targets for Alzheimer's disease Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells.The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease.Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure.Gene-activation mechanisms in the regression of atherosclerosis, elimination of diabetes type 2, and prevention of dementia.Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors.Age-related alterations in the metabolic profile in the hippocampus of the senescence-accelerated mouse prone 8: a spontaneous Alzheimer's disease mouse model.Liver X receptor β protects dopaminergic neurons in a mouse model of Parkinson disease Lxr-driven enterocyte lipid droplet formation delays transport of ingested lipids.Maternal Pre-Pregnancy Obesity Is Associated with Altered Placental Transcriptome Analysis of bioactive oxysterols in newborn mouse brain by LC/MS.

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Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration

http://www.wikidata.org/entity/Q24536348

description

2002 nî lūn-bûn

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2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2002 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2002年の論文

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Liver X receptors in the centr ...... tasis to neuronal degeneration

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Proceedings of the National Academy of Sciences of the United States of America

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Liver X receptors in the centr ...... tasis to neuronal degeneration

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Gertrud U Schuster

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Ling Wang

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Qinghong Zhang

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Sandra Andersson

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P2860

Role of LXRs in control of lipogenesis

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice

Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols

Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system

Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

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21

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Jan-Åke Gustafsson

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11090246

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129791

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