Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4
about
A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cellsA novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95Crystal structure of human CDK4 in complex with a D-type cyclinPP1 and PP2A phosphatases--cooperating partners in modulating retinoblastoma protein activationThe structure of CDK4/cyclin D3 has implications for models of CDK activationRegulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors"Cyclin D1: polymorphism, aberrant splicing and cancer riskA pRb-independent mechanism preserves the postmitotic state in terminally differentiated skeletal muscle cells.PP2A-mediated dephosphorylation of p107 plays a critical role in chondrocyte cell cycle arrest by FGFFirst siRNA library screening in hard-to-transfect HUVEC cells.Perspectives in cell cycle regulation: lessons from an anoxic vertebrate.Genetic replacement of cyclin D1 function in mouse development by cyclin D2.ARF-induced downregulation of Mip130/LIN-9 protein levels mediates a positive feedback that leads to increased expression of p16Ink4a and p19Arf.Oxidative status of muscle is determined by p107 regulation of PGC-1alpha.Integrated stability and activity control of the Drosophila Rbf1 retinoblastoma protein.Regulation of the human catalytic subunit of telomerase (hTERT).Regulation of CDK4Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor developmentCdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence.Pocket protein function in melanocyte homeostasis and neoplasia.Casein kinase II motif-dependent phosphorylation of human papillomavirus E7 protein promotes p130 degradation and S-phase induction in differentiated human keratinocytesRB1, development, and cancer.Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stabilityDifferential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.Deletion of the p107/p130-binding domain of Mip130/LIN-9 bypasses the requirement for CDK4 activity for the dissociation of Mip130/LIN-9 from p107/p130-E2F4 complexKey signaling molecules in pituitary tumors.Signaling through cyclin D-dependent kinases.Magnolol causes alterations in the cell cycle in androgen insensitive human prostate cancer cells in vitro by affecting expression of key cell cycle regulatory proteins.Overexpression of cyclin E/CDK2 complexes overcomes FGF-induced cell cycle arrest in the presence of hypophosphorylated Rb proteinsPEG10 directly regulated by E2Fs might have a role in the development of hepatocellular carcinoma.CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins.G1 cyclin/cyclin-dependent kinase-coordinated phosphorylation of endogenous pocket proteins differentially regulates their interactions with E2F4 and E2F1 and gene expression.Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation.Speeding through cell cycle roadblocks: Nuclear cyclin D1-dependent kinase and neoplastic transformation.DNA damage-dependent cyclin D1 proteolysis: GSK3beta holds the smoking gunCombinatorial PX-866 and Raloxifene Decrease Rb Phosphorylation, Cyclin E2 Transcription, and Proliferation of MCF-7 Breast Cancer Cells.Down-regulation of hTERT and Cyclin D1 transcription via PI3K/Akt and TGF-β pathways in MCF-7 Cancer cells with PX-866 and Raloxifene.Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation.C-terminal sequences direct cyclin D1-CRM1 binding.
P2860
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P2860
Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Reversal of growth suppression ...... n D1/cyclin-dependent kinase 4
@ast
Reversal of growth suppression ...... n D1/cyclin-dependent kinase 4
@en
Reversal of growth suppression ...... n D1/cyclin-dependent kinase 4
@nl
type
label
Reversal of growth suppression ...... n D1/cyclin-dependent kinase 4
@ast
Reversal of growth suppression ...... n D1/cyclin-dependent kinase 4
@en
Reversal of growth suppression ...... n D1/cyclin-dependent kinase 4
@nl
prefLabel
Reversal of growth suppression ...... n D1/cyclin-dependent kinase 4
@ast
Reversal of growth suppression ...... n D1/cyclin-dependent kinase 4
@en
Reversal of growth suppression ...... n D1/cyclin-dependent kinase 4
@nl
P2093
P2860
P1476
Reversal of growth suppression ...... n D1/cyclin-dependent kinase 4
@en
P2093
J Wade Harper
Peter D Adams
Xiaohong Leng
P2860
P304
P356
10.1128/MCB.22.7.2242-2254.2002
P407
P50
P577
2002-04-01T00:00:00Z