Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.
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Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleedingA LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and plateletsAn essential role for RasGRP1 in mast cell function and IgE-mediated allergic responsePlatelet generation in vivo and in vitroAdvances in cellular technology in the hematology field: What have we learned so far?Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical applicationRap1 can bypass the FAK-Src-Paxillin cascade to induce cell spreading and focal adhesion formationMultiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functionsCalDAG-GEFI integrates signaling for platelet aggregation and thrombus formationRap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1A critical function for B-Raf at multiple stages of myelopoiesisADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cellsMyosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes.The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway.Platelet formationMechanisms underlying platelet function defect in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia: potential role for candidate RUNX1 targets.Rasa3 controls megakaryocyte Rap1 activation, integrin signaling and differentiation into proplateletManipulating megakaryocytes to manufacture platelets ex vivo.NF-E2, FLI1 and RUNX1 collaborate at areas of dynamic chromatin to activate transcription in mature mouse megakaryocytesCD98hc (SLC3A2) mediates integrin signaling.Control of cell adhesion dynamics by Rap1 signaling.CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.Rap1b is required for normal platelet function and hemostasis in miceCalDAG-GEFI and platelet activation.Autologous blood cell therapies from pluripotent stem cells.The incredible journey: From megakaryocyte development to platelet formation.Hematopoietic and endothelial differentiation of human induced pluripotent stem cells.Platelets and cancer: a casual or causal relationship: revisited.Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin.The primacy of β1 integrin activation in the metastatic cascade.Arrestin-2 differentially regulates PAR4 and ADP receptor signaling in plateletsGeneration of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium.OP9 bone marrow stroma cells differentiate into megakaryocytes and platelets.Regulation and Function of the RasGRP Family of Ras Activators in Blood CellsContact-dependent signaling during the late events of platelet activation.Gene therapy for platelet disorders: studies with Glanzmann's thrombasthenia.Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signalingEarly block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1.Scientific and clinical opportunities for modeling blood disorders with embryonic stem cells
P2860
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P2860
Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Megakaryocytes derived from em ...... DAG-GEFI in integrin signaling
@nl
Megakaryocytes derived from em ...... AG-GEFI in integrin signaling.
@ast
Megakaryocytes derived from em ...... AG-GEFI in integrin signaling.
@en
type
label
Megakaryocytes derived from em ...... DAG-GEFI in integrin signaling
@nl
Megakaryocytes derived from em ...... AG-GEFI in integrin signaling.
@ast
Megakaryocytes derived from em ...... AG-GEFI in integrin signaling.
@en
prefLabel
Megakaryocytes derived from em ...... DAG-GEFI in integrin signaling
@nl
Megakaryocytes derived from em ...... AG-GEFI in integrin signaling.
@ast
Megakaryocytes derived from em ...... AG-GEFI in integrin signaling.
@en
P2093
P2860
P3181
P356
P1476
Megakaryocytes derived from em ...... AG-GEFI in integrin signaling.
@en
P2093
Alessandra Bertoni
Andrew D Leavitt
Heidi Stuhlmann
Ronan Murphy
Sanford J Shattil
Steve W Kerrigan
Toru Nakano
P2860
P304
12819-12824
P3181
P356
10.1073/PNAS.202380099
P407
P577
2002-09-18T00:00:00Z