Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1 - Wikidata - wikimedia - TriplyDB

Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1

Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1

http://www.wikidata.org/entity/Q24538799

about

Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability Sequencing of 50 human exomes reveals adaptation to high altitude Oxygen sensing in Drosophila: multiple isoforms of the prolyl hydroxylase fatiga have different capacity to regulate HIFalpha/Sima Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2 Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition Hydrogen sulfide increases hypoxia-inducible factor-1 activity independently of von Hippel-Lindau tumor suppressor-1 in C. elegans.CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans.Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system.Latent factor analysis to discover pathway-associated putative segmental aneuploidies in human cancers.Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors The Caenorhabditis elegans rhy-1 gene inhibits HIF-1 hypoxia-inducible factor activity in a negative feedback loop that does not include vhl-1.Regulation of the Sre1 hypoxic transcription factor by oxygen-dependent control of DNA binding.Comparative transcriptomic analysis revealed adaptation mechanism of Phrynocephalus erythrurus, the highest altitude Lizard living in the Qinghai-Tibet Plateau.Quantitative analysis of human immunodeficiency virus type 1-infected CD4+ cell proteome: dysregulated cell cycle progression and nuclear transport coincide with robust virus production EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response.The role of HIF prolyl hydroxylases in tumour growth.Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets.Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegans.BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I.Role of VHL gene mutation in human renal cell carcinoma.Prolyl 4-hydroxylases, master regulators of the hypoxia response.CCL11-induced eosinophils inhibit the formation of blood vessels and cause tumor necrosis.New Insights into Protein Hydroxylation and Its Important Role in Human Diseases.Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis.Effects of YC-1 targeting hypoxia-inducible factor 1 alpha in oesophageal squamous carcinoma cell line Eca109 cells.Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response.Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2.Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains.NDRG3 lowers the metastatic potential in prostate cancer as a feedback controller of hypoxia-inducible factors.Hypoxic Signalling in Tumour Stroma.

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Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1

http://www.wikidata.org/entity/Q24538799

description

2005 nî lūn-bûn

@nan

2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Suppression of hypoxia-inducib ...... e HIF prolyl hydroxylase EGLN1

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Suppression of hypoxia-inducib ...... e HIF prolyl hydroxylase EGLN1

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Suppression of hypoxia-inducib ...... e HIF prolyl hydroxylase EGLN1

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Suppression of hypoxia-inducib ...... e HIF prolyl hydroxylase EGLN1

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Suppression of hypoxia-inducib ...... e HIF prolyl hydroxylase EGLN1

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Suppression of hypoxia-inducib ...... e HIF prolyl hydroxylase EGLN1

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Suppression of hypoxia-inducib ...... e HIF prolyl hydroxylase EGLN1

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Suppression of hypoxia-inducib ...... e HIF prolyl hydroxylase EGLN1

@en

Suppression of hypoxia-inducib ...... e HIF prolyl hydroxylase EGLN1

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Journal of Biological Chemistry

P1476

Suppression of hypoxia-inducib ...... e HIF prolyl hydroxylase EGLN1

@en

P2093

Kenneth K W To

http://www.w3.org/2001/XMLSchema#string

L Eric Huang

http://www.w3.org/2001/XMLSchema#string

P2860

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

A conserved family of prolyl-4-hydroxylases that modify HIF

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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38102-7

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scholarly article

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2676707

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10.1074/JBC.M504342200

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P433

45

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280

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2005-11-11T00:00:00Z

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16157596

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P932

1307502

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