Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets.
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Prolyl 4-hydroxylaseAdipocyte extracellular matrix composition, dynamics and role in obesityThe Crystal Structure of an Algal Prolyl 4-Hydroxylase Complexed with a Proline-rich Peptide Reveals a Novel Buried Tripeptide Binding MotifCrystal Structure of Prolyl 4-Hydroxylase from Bacillus anthracisInhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl CompoundsCole-Carpenter syndrome is caused by a heterozygous missense mutation in P4HBProteomic profiling of follicular and papillary thyroid tumorsMolecular mechanisms of action and therapeutic uses of pharmacological inhibitors of HIF-prolyl 4-hydroxylases for treatment of ischemic diseasesInhibition of 2-oxoglutarate dependent oxygenasesHypoxia--implications for pharmaceutical developmentsMechanisms of fibrosis: therapeutic translation for fibrotic diseaseA miniaturized screen for inhibitors of Jumonji histone demethylases.Extracellular matrix molecules: potential targets in pharmacotherapy.Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injuryCross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetesAdvances in iron chelation: an update.Dihydroceramide-based response to hypoxia.Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney functionExpression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span.Chaperoning osteogenesis: new protein-folding disease paradigms.Extracellular matrix genes as hypoxia-inducible targets.Plasminogen activator inhibitor-1 deficient mice are protected from angiotensin II-induced fibrosisRestoring physiological levels of ascorbate slows tumor growth and moderates HIF-1 pathway activity in Gulo(-/-) mice.Unity in diversity, a systems approach to regulating plant cell physiology by 2-oxoglutarate-dependent dioxygenasesOxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin.Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2.A novel profibrotic mechanism mediated by TGFβ-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cellsSevere Extracellular Matrix Abnormalities and Chondrodysplasia in Mice Lacking Collagen Prolyl 4-Hydroxylase Isoenzyme II in Combination with a Reduced Amount of Isoenzyme I.Selective inhibition of prolyl 4-hydroxylases by bipyridinedicarboxylates.Hypoxia-inducible factor-1 (HIF-1) but not HIF-2 is essential for hypoxic induction of collagen prolyl 4-hydroxylases in primary newborn mouse epiphyseal growth plate chondrocytes.Prolyl 4-hydroxlase activity is essential for development and cuticle formation in the human infective parasitic nematode Brugia malayiHuman prolyl hydroxylase expression in uterine leiomyoma during the menstrual cycle.Mitochondrial metabolites extend lifespan.Selective Inhibition of Collagen Prolyl 4-Hydroxylase in Human CellsExpression, purification, crystallization and preliminary X-ray studies of a prolyl-4-hydroxylase protein from Bacillus anthracis.Transcriptional profiling of rapamycin-treated fibroblasts from hypertrophic and keloid scars.Bioavailable affinity label for collagen prolyl 4-hydroxylase.Alcoholic liver disease and the potential role of plasminogen activator inhibitor-1 and fibrin metabolism.Human Collagen Prolyl 4-Hydroxylase Is Activated by Ligands for Its Iron Center.Prolyl 4-Hydroxylase: Substrate Isosteres in Which an (E)- or (Z)-Alkene Replaces the Prolyl Peptide Bond.
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Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on January 2008
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Prolyl 4-hydroxylases, key enz ...... ir roles as treatment targets.
@en
Prolyl 4-hydroxylases, key enz ...... ir roles as treatment targets.
@nl
type
label
Prolyl 4-hydroxylases, key enz ...... ir roles as treatment targets.
@en
Prolyl 4-hydroxylases, key enz ...... ir roles as treatment targets.
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prefLabel
Prolyl 4-hydroxylases, key enz ...... ir roles as treatment targets.
@en
Prolyl 4-hydroxylases, key enz ...... ir roles as treatment targets.
@nl
P2860
P1433
P1476
Prolyl 4-hydroxylases, key enz ...... ir roles as treatment targets.
@en
P2093
Johanna Myllyharju
P2860
P304
P356
10.1080/07853890801986594
P407
P577
2008-01-01T00:00:00Z