The C-terminal region of hPrp8 interacts with the conserved GU dinucleotide at the 5' splice site
about
Prp8 protein: at the heart of the spliceosomePrp8p dissection reveals domain structure and protein interaction sites.The human Prp8 protein is a component of both U2- and U12-dependent spliceosomesGenetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiaeExtended base pair complementarity between U1 snRNA and the 5' splice site does not inhibit splicing in higher eukaryotes, but rather increases 5' splice site recognitionCrystal structure of the -finger domain of Prp8 reveals analogy to ribosomal proteinsStructure and function of an RNase H domain at the heart of the spliceosomeCrystal structure of Prp8 reveals active site cavity of the spliceosomeStructural basis for dual roles of Aar2p in U5 snRNP assemblyStructure of the yeast U2/U6 snRNA complexA conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligationMolecular architecture of the human U4/U6.U5 tri-snRNPA ribozyme selected from variants of U6 snRNA promotes 2',5'-branch formationThe 100-kda U5 snRNP protein (hPrp28p) contacts the 5' splice site through its ATPase siteRNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core.5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly.Defining a 5' splice site by functional selection in the presence and absence of U1 snRNA 5' end.A general approach for identification of RNA-protein cross-linking sites within native human spliceosomal small nuclear ribonucleoproteins (snRNPs). Analysis of RNA-protein contacts in native U1 and U4/U6.U5 snRNPs.A mutation in a splicing factor that causes retinitis pigmentosa has a transcriptome-wide effect on mRNA splicing.Aberrant splicing of tau pre-mRNA caused by intronic mutations associated with the inherited dementia frontotemporal dementia with parkinsonism linked to chromosome 17.Proximity of the invariant loop of U5 snRNA to the second intron residue during pre-mRNA splicing.Rearrangements within human spliceosomes captured after exon ligation.Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p.Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation.Genetic suppression of intronic +1G mutations by compensatory U1 snRNA changes in Caenorhabditis elegans.Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center.Mobile Bacterial Group II Introns at the Crux of Eukaryotic EvolutionPre-mRNA splicing and retinitis pigmentosaEvaluation of splicing efficiency in lymphoblastoid cell lines from patients with splicing-factor retinitis pigmentosa.The conserved 3' end domain of U6atac snRNA can direct U6 snRNA to the minor spliceosome.The spliceosome as ribozyme hypothesis takes a second step.Splicing of mRNA precursors: the role of RNAs and proteins in catalysis.The spliceosomal proteome: at the heart of the largest cellular ribonucleoprotein machine.Structural studies of the spliceosome: zooming into the heart of the machine.Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans.Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5' splice site.The U1 snRNP base pairs with the 5' splice site within a penta-snRNP complex.Genetics and biochemistry remain essential in the structural era of the spliceosome.Emerging views about the molecular structure of the spliceosomal catalytic center.
P2860
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P2860
The C-terminal region of hPrp8 interacts with the conserved GU dinucleotide at the 5' splice site
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The C-terminal region of hPrp8 ...... cleotide at the 5' splice site
@ast
The C-terminal region of hPrp8 ...... cleotide at the 5' splice site
@en
The C-terminal region of hPrp8 ...... cleotide at the 5' splice site
@nl
type
label
The C-terminal region of hPrp8 ...... cleotide at the 5' splice site
@ast
The C-terminal region of hPrp8 ...... cleotide at the 5' splice site
@en
The C-terminal region of hPrp8 ...... cleotide at the 5' splice site
@nl
prefLabel
The C-terminal region of hPrp8 ...... cleotide at the 5' splice site
@ast
The C-terminal region of hPrp8 ...... cleotide at the 5' splice site
@en
The C-terminal region of hPrp8 ...... cleotide at the 5' splice site
@nl
P2093
P2860
P1433
P1476
The C-terminal region of hPrp8 ...... cleotide at the 5' splice site
@en
P2093
P2860
P304
P356
10.1017/S1355838299981785
P407
P577
1999-02-01T00:00:00Z