Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.
about
A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site.Prp8 protein: at the heart of the spliceosomePrp8p dissection reveals domain structure and protein interaction sites.An upstream AG determines whether a downstream AG is selected during catalytic step II of splicingThe spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctionsPre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctionsExtended base pair complementarity between U1 snRNA and the 5' splice site does not inhibit splicing in higher eukaryotes, but rather increases 5' splice site recognitionThe architecture of the spliceosomal U4/U6.U5 tri-snRNP.Crystal structure of the functional domain of the splicing factor Prp18Crystal structure of the -finger domain of Prp8 reveals analogy to ribosomal proteinsStructure and function of an RNase H domain at the heart of the spliceosomeStructural basis for dual roles of Aar2p in U5 snRNP assemblyA conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligationStructure of a yeast spliceosome at 3.6-angstrom resolutionEvidence for a role of Sky1p-mediated phosphorylation in 3' splice site recognition involving both Prp8 and Prp17/Slu4.Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly.Spatial organization of protein-RNA interactions in the branch site-3' splice site region during pre-mRNA splicing in yeast.The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing.Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing.CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome.Molecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system.Central region of the human splicing factor Hprp3p interacts with Hprp4pATP-dependent interaction of yeast U5 snRNA loop 1 with the 5' splice site.Characterization of U4 and U6 interactions with the 5' splice site using a S. cerevisiae in vitro trans-splicing systemA ribozyme selected from variants of U6 snRNA promotes 2',5'-branch formationThe 100-kda U5 snRNP protein (hPrp28p) contacts the 5' splice site through its ATPase siteDefining a 5' splice site by functional selection in the presence and absence of U1 snRNA 5' end.A general approach for identification of RNA-protein cross-linking sites within native human spliceosomal small nuclear ribonucleoproteins (snRNPs). Analysis of RNA-protein contacts in native U1 and U4/U6.U5 snRNPs.From the ribosome to the spliceosome and back again.Analysis of the splicing machinery in fission yeast: a comparison with budding yeast and mammals.Interaction of the yeast DExH-box RNA helicase prp22p with the 3' splice site during the second step of nuclear pre-mRNA splicingSplicing factor slt11p and its involvement in formation of U2/U6 helix II in activation of the yeast spliceosomeDistinct domains of splicing factor Prp8 mediate different aspects of spliceosome activationProximity of the invariant loop of U5 snRNA to the second intron residue during pre-mRNA splicing.A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast.Splicing enhancement in the yeast rp51b intron.Identification of a U2/U6 helix la mutant that influences 3' splice site selection during nuclear pre-mRNA splicing.Genetic interactions between the 5' and 3' splice site consensus sequences and U6 snRNA during the second catalytic step of pre-mRNA splicing.The conserved central domain of yeast U6 snRNA: importance of U2-U6 helix Ia in spliceosome assembly.UAP56 levels affect viability and mRNA export in Caenorhabditis elegans.
P2860
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P2860
Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.
description
1999 nî lūn-bûn
@nan
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Allele-specific genetic intera ...... lytic core of the spliceosome.
@ast
Allele-specific genetic intera ...... lytic core of the spliceosome.
@en
type
label
Allele-specific genetic intera ...... lytic core of the spliceosome.
@ast
Allele-specific genetic intera ...... lytic core of the spliceosome.
@en
prefLabel
Allele-specific genetic intera ...... lytic core of the spliceosome.
@ast
Allele-specific genetic intera ...... lytic core of the spliceosome.
@en
P2860
P356
P1433
P1476
Allele-specific genetic intera ...... alytic core of the spliceosome
@en
P2093
P2860
P304
P356
10.1101/GAD.13.15.1970
P577
1999-08-01T00:00:00Z