CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis - Wikidata - wikimedia - TriplyDB

CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis

CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis

http://www.wikidata.org/entity/Q24540387

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p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2 Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1)Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle.Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton.RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer Structural Basis of Targeting the Exportin CRM1 in Cancer Nuclear export of proteins and drug resistance in cancer Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression cPLA2-interacting protein, PLIP, causes apoptosis and decreases G1 phase in mesangial cells PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells.p27Kip1 localization depends on the tumor suppressor protein tuberin.p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway.Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids.Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer.hMSH5 is a nucleocytoplasmic shuttling protein whose stability depends on its subcellular localization.The severe acute respiratory syndrome coronavirus nucleocapsid protein is phosphorylated and localizes in the cytoplasm by 14-3-3-mediated translocation.A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agents Phosphorylation and subcellular localization of p27Kip1 regulated by hydrogen peroxide modulation in cancer cells p27: a barometer of signaling deregulation and potential predictor of response to targeted therapies.Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism.Hunk is required for HER2/neu-induced mammary tumorigenesis.A novel germline CDKN1B mutation causing multiple endocrine tumors: clinical, genetic and functional characterization.p27(Kip1), a double-edged sword in Shh-mediated medulloblastoma: Tumor accelerator and suppressor.Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation.Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds Evidence for PTEN-independent Akt activation and Akt-independent p27(Kip1) expression in advanced bladder cancer.p27Kip1 Is Required to Mediate a G1 Cell Cycle Arrest Downstream of ATM following Genotoxic Stress Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia The priming/completion paradigm to explain growth factor-dependent cell cycle progression.Identification of a nuclear export signal sequence for bovine papillomavirus E1 protein.Targeting of cytosolic phospholipase A2α impedes cell cycle re-entry of quiescent prostate cancer cells.Cyclin-dependent kinase inhibitors in yeast, animals, and plants: a functional comparison.CRM1 inhibitor S109 suppresses cell proliferation and induces cell cycle arrest in renal cancer cells.The non-canonical functions of p27(Kip1) in normal and tumor biology.

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CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis

http://www.wikidata.org/entity/Q24540387

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2003 nî lūn-bûn

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2003 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2003 թվականի հունվարին հրատարակված գիտական հոդված

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2003年の論文

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name

CRM1/Ran-mediated nuclear expo ...... nks p27 export and proteolysis

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CRM1/Ran-mediated nuclear expo ...... nks p27 export and proteolysis

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CRM1/Ran-mediated nuclear expo ...... nks p27 export and proteolysis

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CRM1/Ran-mediated nuclear expo ...... nks p27 export and proteolysis

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CRM1/Ran-mediated nuclear expo ...... nks p27 export and proteolysis

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CRM1/Ran-mediated nuclear expo ...... nks p27 export and proteolysis

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CRM1/Ran-mediated nuclear expo ...... nks p27 export and proteolysis

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CRM1/Ran-mediated nuclear expo ...... nks p27 export and proteolysis

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CRM1/Ran-mediated nuclear expo ...... nks p27 export and proteolysis

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MBC.E02-06-0319

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Molecular Biology of the Cell

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CRM1/Ran-mediated nuclear expo ...... nks p27 export and proteolysis

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Ansgar Resch

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Joyce M Slingerland

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Michael K Connor

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Rafaella Lupetti

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Richard G Beniston

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Rouslan Kotchetkov

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Sandrine Cariou

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P2860

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

T RANSPORT B ETWEEN THE C ELL N UCLEUS AND THE C YTOPLASM

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.

New functional activities for the p21 family of CDK inhibitors

Characterization and targeted disruption of murine Nup50, a p27(Kip1)-interacting component of the nuclear pore complex

Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export

The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B

Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells

Nuclear localization of cyclin B1 controls mitotic entry after DNA damage

Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

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201-213

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scholarly article

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1005271

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10.1091/MBC.E02-06-0319

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1

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14

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Frauke Melchior

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2003-01-01T00:00:00Z

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12529437

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140238

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