Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1
about
Total sequence decomposition distinguishes functional modules, "molegos" in apurinic/apyrimidinic endonucleasesConserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair EnzymesStructure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg2+cofactorOverexpression of the human HAP1 protein sensitizes cells to the lethal effect of bioreductive drugsDynamics of the interaction of human apurinic endonuclease (Ape1) with its substrate and productMutations in the alpha8 loop of human APE1 alter binding and cleavage of DNA containing an abasic site.Substitution of Asp-210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilises substrate binding.Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell linesAn AP endonuclease functions in active DNA demethylation and gene imprinting in Arabidopsis [corrected].Characterization of the endoribonuclease active site of human apurinic/apyrimidinic endonuclease 1.Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family.Essential role for mammalian apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere maintenance.Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions.Transient-state kinetics of apurinic/apyrimidinic (AP) endonuclease 1 acting on an authentic AP site and commonly used substrate analogs: the effect of diverse metal ions and base mismatches.Crystal structure of the endonuclease domain encoded by the telomere-specific long interspersed nuclear element, TRAS1.MD simulation and experimental evidence for Mg²+ binding at the B site in human AP endonuclease 1.Expression levels of the DNA repair enzyme HAP1 do not correlate with the radiosensitivities of human or HAP1-transfected rat cell lines.The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sitesChinese hamster AP endonuclease operates by a two-metal ion assisted catalytic mechanism.
P2860
Q24797920-55C7584D-26EF-4AC5-9554-B5E86E649EC1Q27676022-B00D8B46-2225-4F3F-920E-3E09EFEEE8F1Q27680779-1AA352F9-9EDC-4F7D-8544-46A0F6195C12Q28373081-2F507DCC-B41D-4F2A-9140-BBEE18971F08Q28609218-782083C1-432C-4967-8EE6-50BF6A9B047DQ31156442-44D49055-BADE-48BB-B783-D232170C8A1FQ33615904-E1F12E6B-70ED-4981-919C-0B0D10A9B332Q34627873-2F0C3165-364A-4F3A-BDF0-13C79AA55A06Q34873526-D1A52FE7-B548-4AB8-B68F-815A2C72952FQ36137857-1010248E-F200-43D7-A7CC-8C5370ABA86FQ37149762-952AFEBF-2E33-4920-BF1A-31EDC3B5809BQ37276446-857963C2-56C6-4915-91E7-BB0060AC7CD3Q37379745-93500545-B7B7-479C-94FA-5A86AA4D48B6Q37385029-8EA6C80D-13E7-4D64-842C-438128FC10C6Q38339071-BC85249D-039D-4872-9665-9864B2911FEFQ39175286-0754DDA3-15E0-45C9-B0CE-5C265E06307FQ40949690-CAE6A959-5E1B-483F-92A1-BD738AAD45A8Q42631836-90DDA6B6-C7D3-4A25-BA6F-79D58437A5F8Q50505059-9184EAE7-3880-4546-8598-9265D11CB2EC
P2860
Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1
description
1996 nî lūn-bûn
@nan
1996 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Asparagine 212 is essential fo ...... n DNA repair endonuclease HAP1
@ast
Asparagine 212 is essential fo ...... n DNA repair endonuclease HAP1
@en
Asparagine 212 is essential fo ...... n DNA repair endonuclease HAP1
@nl
type
label
Asparagine 212 is essential fo ...... n DNA repair endonuclease HAP1
@ast
Asparagine 212 is essential fo ...... n DNA repair endonuclease HAP1
@en
Asparagine 212 is essential fo ...... n DNA repair endonuclease HAP1
@nl
prefLabel
Asparagine 212 is essential fo ...... n DNA repair endonuclease HAP1
@ast
Asparagine 212 is essential fo ...... n DNA repair endonuclease HAP1
@en
Asparagine 212 is essential fo ...... n DNA repair endonuclease HAP1
@nl
P2860
P356
P1476
Asparagine 212 is essential fo ...... n DNA repair endonuclease HAP1
@en
P2093
D G Rothwell
I D Hickson
P2860
P304
P356
10.1093/NAR/24.21.4217
P407
P577
1996-11-01T00:00:00Z