Dynamics of the interaction of human apurinic endonuclease (Ape1) with its substrate and product
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Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme ATotal sequence decomposition distinguishes functional modules, "molegos" in apurinic/apyrimidinic endonucleasesDNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]Solution structure of an oligonucleotide containing an abasic site: evidence for an unusual deoxyribose conformationSynthesis, characterization and solution structure of tethered oligonucleotides containing an internal 3'-phosphoglycolate, 5'-phosphate gapped lesionDNA oligonucleotides with A, T, G or C opposite an abasic site: structure and dynamicsDNA apurinic-apyrimidinic site binding and excision by endonuclease IVConserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair EnzymesApurinic endonuclease activity of yeast Apn2 protein.Deoxycytidyl transferase activity of the human REV1 protein is closely associated with the conserved polymerase domainRole of single-stranded DNA in targeting REV1 to primer terminiGenetic and biochemical characterization of human AP endonuclease 1 mutants deficient in nucleotide incision repair activityProteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interactionStimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repairEnhanced activity of adenine-DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatchUnusual role of a cysteine residue in substrate binding and activity of human AP-endonuclease 1.Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.Mutations in the alpha8 loop of human APE1 alter binding and cleavage of DNA containing an abasic site.Cross-talk-free dual-color fluorescence cross-correlation spectroscopy for the study of enzyme activity.Substitution of Asp-210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilises substrate binding.African swine fever virus AP endonuclease is a redox-sensitive enzyme that repairs alkylating and oxidative damage to DNA.Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP endonuclease: bypass of the AP lyase activity stepEffect of protein binding on ultrafast DNA dynamics: characterization of a DNA:APE1 complex.Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function3CAPS - a structural AP-site analogue as a tool to investigate DNA base excision repair.Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family.APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation.Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair.Heat shock protein 70 binds to human apurinic/apyrimidinic endonuclease and stimulates endonuclease activity at abasic sites.Crystal structure of the endonuclease domain encoded by the telomere-specific long interspersed nuclear element, TRAS1.Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity.Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology.The Saccharomyces cerevisiae ETH1 gene, an inducible homolog of exonuclease III that provides resistance to DNA-damaging agents and limits spontaneous mutagenesis.Assembly of the base excision repair complex on abasic DNA and role of adenomatous polyposis coli on its functional activity.Role of active site tyrosines in dynamic aspects of DNA binding by AP endonuclease.Human AP endonuclease 1 stimulates multiple-turnover base excision by alkyladenine DNA glycosylaseCovalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone.Functional role of HIV-1 virion-associated uracil DNA glycosylase 2 in the correction of G:U mispairs to G:C pairs.Modulation of the 3'-->5'-exonuclease activity of human apurinic endonuclease (Ape1) by its 5'-incised Abasic DNA product.Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin).
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Dynamics of the interaction of human apurinic endonuclease (Ape1) with its substrate and product
description
1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
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artículu científicu espublizáu en 1998
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im November 1998 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 1998/11/13)
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vědecký článek publikovaný v roce 1998
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wetenschappelijk artikel (gepubliceerd op 1998/11/13)
@nl
наукова стаття, опублікована в листопаді 1998
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name
Dynamics of the interaction of ...... with its substrate and product
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Dynamics of the interaction of ...... with its substrate and product
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Dynamics of the interaction of ...... with its substrate and product
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Dynamics of the interaction of ...... with its substrate and product
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Dynamics of the interaction of ...... with its substrate and product
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Dynamics of the interaction of ...... with its substrate and product
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prefLabel
Dynamics of the interaction of ...... with its substrate and product
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Dynamics of the interaction of ...... with its substrate and product
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Dynamics of the interaction of ...... with its substrate and product
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Dynamics of the interaction of ...... with its substrate and product
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R. A. Bennett
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30352–30359
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10.1074/JBC.273.46.30352
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P577
1998-11-13T00:00:00Z