Uncleaved TFIIA is a substrate for taspase 1 and active in transcription - Wikidata - wikimedia - TriplyDB

Uncleaved TFIIA is a substrate for taspase 1 and active in transcription

Uncleaved TFIIA is a substrate for taspase 1 and active in transcription

http://www.wikidata.org/entity/Q24548040

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Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2 The super elongation complex (SEC) and MLL in development and disease.Bioassays to monitor Taspase1 function for the identification of pharmacogenetic inhibitors Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs Activity of the upstream TATA-less promoter of the p21(Waf1/Cip1) gene depends on transcription factor IIA (TFIIA) in addition to TFIIA-reactive TBP-like protein.A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis.Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.MLL becomes functional through intra-molecular interaction not by proteolytic processing Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription.Structural Characterization of the Loop at the Alpha-Subunit C-Terminus of the Mixed Lineage Leukemia Protein Activating Protease Taspase1.Taspase1 processing alters TFIIA cofactor properties in the regulation of TFIID.Species selectivity of mixed-lineage leukemia/trithorax and HCF proteolytic maturation pathways.Design, syntheses, and evaluation of Taspase1 inhibitors HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma.Taspase 1: A protease with many biological surprises.TRF2 is recruited to the pre-initiation complex as a testis-specific subunit of TFIIA/ALF to promote haploid cell gene expression."Targeting Taspase1 for Cancer Therapy"-Response Taspase1: a 'misunderstood' protease with translational cancer relevance.TBP-like protein (TLP) interferes with Taspase1-mediated processing of TFIIA and represses TATA box gene expression.Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4-MLL Fusion Protein The importin-alpha/nucleophosmin switch controls taspase1 protease function.Cell-based analysis of structure-function activity of threonine aspartase 1 TFIIB recognition elements control the TFIIA-NC2 axis in transcriptional regulation.Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions.Identification of Pep4p as the protease responsible for formation of the SAGA-related SLIK protein complex.Protease addiction and synthetic lethality in cancer.Processing the complexities of transcription.Disease-relevant signalling-pathways in head and neck cancer: Taspase1's proteolytic activity fine-tunes TFIIA function.TFIIA transcriptional activity is controlled by a 'cleave-and-run' Exportin-1/Taspase 1-switch.A transcription factor IIA-binding site differentially regulates RNA polymerase II-mediated transcription in a promoter context-dependent manner.Ubiquitin-proteasome-dependent degradation of TBP-like protein is prevented by direct binding of TFIIA.iTRAQ Protein Profile Differential Analysis of Dormant and Germinated Grassbur Twin Seeds Reveals that Ribosomal Synthesis and Carbohydrate Metabolism Promote Germination Possibly Through the PI3K Pathway.A Strategy To Isolate Modifiers of Caenorhabditis elegans Lethal Mutations: Investigating the Endoderm Specifying Ability of the Intestinal Differentiation GATA Factor ELT-2.Evolution of Eukaryotic Chromatin Proteins and Transcription Factors

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Uncleaved TFIIA is a substrate for taspase 1 and active in transcription

http://www.wikidata.org/entity/Q24548040

description

2006 nî lūn-bûn

@nan

2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի ապրիլին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Uncleaved TFIIA is a substrate for taspase 1 and active in transcription

@ast

Uncleaved TFIIA is a substrate for taspase 1 and active in transcription

@en

Uncleaved TFIIA is a substrate for taspase 1 and active in transcription

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type

label

Uncleaved TFIIA is a substrate for taspase 1 and active in transcription

@ast

Uncleaved TFIIA is a substrate for taspase 1 and active in transcription

@en

Uncleaved TFIIA is a substrate for taspase 1 and active in transcription

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prefLabel

Uncleaved TFIIA is a substrate for taspase 1 and active in transcription

@ast

Uncleaved TFIIA is a substrate for taspase 1 and active in transcription

@en

Uncleaved TFIIA is a substrate for taspase 1 and active in transcription

@nl

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P356

MCB.26.7.2728-2735.2006

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Molecular and Cellular Biology

P1476

Uncleaved TFIIA is a substrate for taspase 1 and active in transcription

@en

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Dimitra J Mitsiou

http://www.w3.org/2001/XMLSchema#string

Hendrik G Stunnenberg

http://www.w3.org/2001/XMLSchema#string

Huiqing Zhou

http://www.w3.org/2001/XMLSchema#string

James J-D Hsieh

http://www.w3.org/2001/XMLSchema#string

Stanley J Korsmeyer

http://www.w3.org/2001/XMLSchema#string

Torill Høiby

http://www.w3.org/2001/XMLSchema#string

P2860

Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression

Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription

Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription

Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes

Crystal structure of a yeast TFIIA/TBP/DNA complex

The TBP-TFIIA interaction in the response to acidic activators in vivo.

Intermediates in formation and activity of the RNA polymerase II preinitiation complex: holoenzyme recruitment and a postrecruitment role for the TATA box and TFIIB.

Specialized and redundant roles of TBP and a vertebrate-specific TBP paralog in embryonic gene regulation in Xenopus

Proteolytic cleavage of ALF into alpha- and beta-subunits that form homologous and heterologous complexes with somatic TFIIA and TRF2 in male germ cells

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2728-2735

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scholarly article

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3803369

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10.1128/MCB.26.7.2728-2735.2006

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7

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26

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Gert Jan C Veenstra

Salvatore Spicuglia

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2006-04-01T00:00:00Z

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7240543

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16537915

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1430320

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