The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion - Wikidata - wikimedia - TriplyDB

The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion

The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion

http://www.wikidata.org/entity/Q24550570

about

The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta Smad inhibition by the Ste20 kinase Misshapen Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase Genome-wide review of transcriptional complexity in mouse protein kinases and phosphatases.Agonistic and antagonistic roles for TNIK and MINK in non-canonical and canonical Wnt signalling Intracellular Theileria annulata promote invasive cell motility through kinase regulation of the host actin cytoskeleton MAP4K4: an emerging therapeutic target in cancer Applying ligands profiling using multiple extended electron distribution based field templates and feature trees similarity searching in the discovery of new generation of urea-based antineoplastic kinase inhibitors The Nck-interacting kinase phosphorylates ERM proteins for formation of lamellipodium by growth factors.The Ste20 kinase misshapen is essential for the invasive behaviour of ovarian epithelial cells in Drosophila.Misshapen decreases integrin levels to promote epithelial motility and planar polarity in Drosophila The Nck-interacting kinase NIK increases Arp2/3 complex activity by phosphorylating the Arp2 subunit Trait correlated expression combined with expression QTL analysis reveals biological pathways and candidate genes affecting water holding capacity of muscle.RNAi screens reveal novel metabolic regulators: RIP140, MAP4k4 and the lipid droplet associated fat specific protein (FSP) 27.Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres.Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and radioresistance Gene transfer efficiency and genome-wide integration profiling of Sleeping Beauty, Tol2, and piggyBac transposons in human primary T cells The Ser/Thr kinase MAP4K4 drives c-Met-induced motility and invasiveness in a cell-based model of SHH medulloblastoma Integration of gene expression profiling and clinical variables to predict prostate carcinoma recurrence after radical prostatectomy Round and round gets you somewhere: collective cell migration and planar polarity in elongating Drosophila egg chambers.Maternal Nanos represses hid/skl-dependent apoptosis to maintain the germ line in Drosophila embryos.Prognostic and Functional Significance of MAP4K5 in Pancreatic Cancer.MiR-194, commonly repressed in colorectal cancer, suppresses tumor growth by regulating the MAP4K4/c-Jun/MDM2 signaling pathway.Silencing of MAP4K4 by short hairpin RNA suppresses proliferation, induces G1 cell cycle arrest and induces apoptosis in gastric cancer cells.Structure, functional regulation and signaling properties of Rap2B.Map4k4 Signaling Nodes in Metabolic and Cardiovascular Diseases A Novel Interaction between Pyk2 and MAP4K4 Is Integrated with Glioma Cell Migration Diagnostic and prognostic biomarkers in pancreatic carcinoma.GLK/MAP4K3 overexpression associates with recurrence risk for non-small cell lung cancer.Hsa-let-7c-5p augments enterovirus 71 replication through viral subversion of cell signaling in rhabdomyosarcoma cells The prognostic role of intragenic copy number breakpoints and identification of novel fusion genes in paediatric high grade glioma.Targeting kinases for the treatment of inflammatory diseases.Lowered HGK expression inhibits cell invasion and adhesion in hepatocellular carcinoma cell line HepG2.Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis.Role of microRNA-141 in colorectal cancer with lymph node metastasis.Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2.MAP4K4 controlled integrin β1 activation and c-Met endocytosis are associated with invasive behavior of medulloblastoma cells.

P2860

Q24302294-A1D7DBFE-8A3E-4247-B564-A6707A89C462 Q24306485-AAE1A5A0-E42F-4BB6-841E-2D57F913C44E Q24307319-EAD05418-1D5F-4FEC-BFED-9DF625CD21D6 Q24308598-E30D25B7-FC02-42B7-AE30-DABD2EA23E0B Q24541417-702F5B1D-F083-40F3-9445-449CAD2B0E38 Q24548067-5DC4C66A-A05B-4070-89CE-426D609FE69D Q27323158-6BD5A847-FD59-4CBB-B057-B38AEEF3A9B5 Q27329799-1C34336B-C086-407E-A238-B8A5219F0F6D Q28068524-3A42B657-47ED-43D6-B3FF-524D84AE838C Q28485281-4F837342-B471-4754-B57F-8398EA44CFE5 Q30477995-F9DBFA01-AAA0-4397-8DD4-CB76D32C5D51 Q30497620-79FF90AE-07FB-4C35-B35F-D5595B61B037 Q30537787-B4EBD91D-161A-4C07-981C-1AD293AA006F Q30616543-CDE5043E-390D-4B2A-B545-E312B5051B41 Q33356807-E78B9688-FC7A-4E42-9350-D5CFF0408974 Q33893209-70E10990-D66D-4476-8442-A98095877221 Q33961341-7F89AFE7-8A5E-444E-A822-0C10A0725B76 Q34105339-F3344F00-F248-426A-8323-E036C02E989E Q34183381-E0A39BAD-919D-4FEC-A5B7-35ED88F2A5E2 Q34996463-D261F049-21C6-495A-837C-186ACCA6645E Q35751889-61CE0EEF-BC14-400A-B77B-EFF1A2B164B4 Q35751925-C9CB5788-CAE4-4F8D-9630-10553D52F71A Q35756940-6989D57E-69B6-44D4-9DB5-8CEC35B4767B Q35972844-BF48DEAD-5EEE-4DE8-BF24-4D66FDF13C37 Q36189343-0D6C0C8A-3B07-47A5-9D47-0C1566004CD1 Q36390246-3FF8E877-4F2E-4995-B42C-F5778F53F33F Q36741049-8539DA2B-D76E-490F-9F2E-1A0231D2A93F Q37018393-DE82C1E7-CFC4-4F34-BF10-2239830F2290 Q37218700-866D731C-2C8F-48DA-B4B4-86525DF7BC4C Q37284685-B3B9649A-D521-42A5-8C6B-A22896CB566F Q37520347-4B6A0E49-32E2-44E7-8572-E92A650D722D Q37587167-937972AA-106B-40B0-9F74-1E5A6185B862 Q37609740-41C8B603-7050-4B20-A63B-47F56A2211D3 Q38028572-893FC687-17E8-4760-89C3-4E2E2FFF3E1F Q39653254-79F9D88D-6839-46D6-90CC-1849EA13C253 Q39790200-A93D51B4-7423-447C-B8B1-046E6A4BCE9F Q41761571-80139438-C66A-432B-A20D-2BFE2EA1BB45 Q42370696-DA494C8F-5F6A-42DB-9F08-EBBD45554D48 Q42828385-45CA78C1-D37E-4513-A142-E7DFC5904A76 Q54978310-7EA6CD16-F0C2-4D4B-878E-F416F5707F12

P2860

The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion

http://www.wikidata.org/entity/Q24550570

description

2003 nî lūn-bûn

@nan

2003 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի մարտին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

The STE20 kinase HGK is broadl ...... mation, invasion, and adhesion

@ast

The STE20 kinase HGK is broadl ...... mation, invasion, and adhesion

@en

The STE20 kinase HGK is broadl ...... mation, invasion, and adhesion

@nl

type

label

The STE20 kinase HGK is broadl ...... mation, invasion, and adhesion

@ast

The STE20 kinase HGK is broadl ...... mation, invasion, and adhesion

@en

The STE20 kinase HGK is broadl ...... mation, invasion, and adhesion

@nl

prefLabel

The STE20 kinase HGK is broadl ...... mation, invasion, and adhesion

@ast

The STE20 kinase HGK is broadl ...... mation, invasion, and adhesion

@en

The STE20 kinase HGK is broadl ...... mation, invasion, and adhesion

@nl

P1433

Q24550570-7F970098-C915-49A9-899B-CDB00586A427

P1476

Q24550570-CE91E987-9CE6-405F-B752-733F502651DB

P2093

Q24550570-0020785C-B520-4304-8685-A5B87895F4BB

Q24550570-09492957-B234-4B79-ADB0-95DC999C737B

Q24550570-531BE7A7-EEF4-4B4E-912F-F68FBC74D166

Q24550570-56EE8BF9-8354-49A3-8B80-CDF464806F92

Q24550570-5BBC3B2A-EFB1-452E-ADCD-3378218B49F6

Q24550570-6F07EC4D-02C9-4C05-B024-75D1F7C29A2D

Q24550570-871635A1-88A5-49D0-BE89-62AE6CA9F206

Q24550570-97B59B32-A346-4FF1-845A-E3EC3EDEEA97

Q24550570-AFAE1550-1386-4626-9EC0-53DB8E7369DE

Q24550570-BE3EC470-A947-41E7-8102-82AD81946E2F

P2860

Q24550570-04679D33-05EB-4557-803F-1DA0A55E0725

Q24550570-07E309F0-DC57-444B-A287-1F3111E80F05

Q24550570-0AD42FAA-9FFB-40D5-9CEA-0E2C18913E76

Q24550570-0E5254BC-5557-41D3-B1EA-F08A6A40DEC9

Q24550570-0FE928AA-FF09-4CFF-820A-536C21EBCEC9

Q24550570-1039E990-5698-462E-ADC0-D4D2EC82E82B

Q24550570-12A941E9-5ACF-41B6-895B-99BBA413F64C

Q24550570-12E257CD-94E6-481B-8381-1A7E87A1F4CA

Q24550570-1F9B59B4-F119-431B-9E05-4F263ABA8C9B

Q24550570-28E3F9CB-FDEA-4A56-ADE7-810214FDAFBA

P304

Q24550570-C33F8E06-C607-437F-8C1A-CD37BD8F2B9A

P31

Q24550570-B8A3FE35-1B46-4A1C-B0BB-896612F60330

P3181

Q24550570-23F0B4DC-C079-42B1-B702-16C729AD6969

P356

Q24550570-30E47F29-778E-4707-A01C-EF962E6B2D1E

P407

Q24550570-C5663298-73BF-4C14-BF35-62B2BD5A9A45

P433

Q24550570-1B406BE2-4681-4558-ACAB-4D594B6D820F

P478

Q24550570-3F8D1FC8-63C5-48DB-ADEA-70CE7BD18A83

P50

Q24550570-1949739B-D9F2-4634-992B-1E6961C8FBFC

Q24550570-5D237242-6F3F-4146-B27F-4903FDC43114

Q24550570-B448CA66-4F9F-400D-B7D6-487912B33090

P577

Q24550570-520DD09C-A0DA-4E2C-A988-73D487BC65B9

P698

Q24550570-1813070F-8E87-48CC-B353-EC90CCABAF0A

P921

Q24550570-7EF5DC2D-50FA-464D-87B9-0B7920B19D01

P932

Q24550570-3F19C22B-F333-4601-AF9D-5D45F5E5BBBC

P3181

P356

MCB.23.6.2068-2082.2003

P1433

Molecular and Cellular Biology

P1476

The STE20 kinase HGK is broadl ...... mation, invasion, and adhesion

@en

P2093

Anthony R Howlett

http://www.w3.org/2001/XMLSchema#string

Bahija Jallal

http://www.w3.org/2001/XMLSchema#string

Brandon J LaMere

http://www.w3.org/2001/XMLSchema#string

David B Whyte

http://www.w3.org/2001/XMLSchema#string

James R Bischoff

http://www.w3.org/2001/XMLSchema#string

Jocelyn H Wright

http://www.w3.org/2001/XMLSchema#string

Peter M Flanagan

http://www.w3.org/2001/XMLSchema#string

Phuong Le

http://www.w3.org/2001/XMLSchema#string

Sharon D Buckley

http://www.w3.org/2001/XMLSchema#string

Shirley Zhu

http://www.w3.org/2001/XMLSchema#string

P2860

Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron

A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway

TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development

Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.

Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase

The protein kinase complement of the human genome

NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation

P304

2068-82

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

2754488

http://www.w3.org/2001/XMLSchema#string

P356

10.1128/MCB.23.6.2068-2082.2003

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

23

http://www.w3.org/2001/XMLSchema#string

P50

Kenneth E. Lipson

Deepak B Khatry

P577

2003-03-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

12612079

http://www.w3.org/2001/XMLSchema#string

P921

P932

149462

http://www.w3.org/2001/XMLSchema#string