Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf
about
Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome traffickingThe tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesisOligomerization of DH domain is essential for Dbl-induced transformationThe Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling propertiesRasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responsesStimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)Contrasting roles of neuronal Msk1 and Rsk2 in Bad phosphorylation and feedback regulation of Erk signallingPhosphorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortexp75-Ras-GRF1 is a c-Jun/AP-1 target protein: its up regulation results in increased Ras activity and is necessary for c-Jun-induced nonadherent growth of Rat1a cellsIdentification of novel RasGRF1 interacting partners by large-scale proteomic analysis.The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdc42-binding CZH2 domain.Sites of phosphorylation by protein kinase A in CDC25Mm/GRF1, a guanine nucleotide exchange factor for Ras.Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA.Leucine zipper-mediated homo-oligomerization regulates the Rho-GEF activity of AKAP-Lbc.Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1.Calmodulin-independent coordination of Ras and extracellular signal-regulated kinase activation by Ras-GRF2.Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways.p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB.Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells.Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development.Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration.A role for the noncatalytic N terminus in the function of Cdc25, a Saccharomyces cerevisiae Ras-guanine nucleotide exchange factor.Calcium signaling in the nucleus.Efficient intracellular assembly of papillomaviral vectorsPleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line.Filamin A-mediated down-regulation of the exchange factor Ras-GRF1 correlates with decreased matrix metalloproteinase-9 expression in human melanoma cells.HSos1 contains a new amino-terminal regulatory motif with specific binding affinity for its pleckstrin homology domain.Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium.A dominant negative RAS-specific guanine nucleotide exchange factor reverses neoplastic phenotype in K-ras transformed mouse fibroblasts.Induction of rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) following phosphorylation by the nonreceptor tyrosine kinase Src.The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity.RasGRF Couples Nox4-Dependent Endoplasmic Reticulum Signaling to Ras.The Rho family GTPase Cdc42 regulates the activation of Ras/MAP kinase by the exchange factor Ras-GRF.The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms.Phosphorylation of serine 916 of Ras-GRF1 contributes to the activation of exchange factor activity by muscarinic receptors.CDC25(Mm)/Ras-GRF1 regulates both Ras and Rac signaling pathways.Sensitivity of wild type and mutant ras alleles to Ras specific exchange factors: Identification of factor specific requirements.Oligomerization regulates the localization of Cdc24, the Cdc42 activator in Saccharomyces cerevisiae.
P2860
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P2860
Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Ras-specific exchange factor G ...... um-dependent activation of Raf
@ast
Ras-specific exchange factor G ...... um-dependent activation of Raf
@en
Ras-specific exchange factor G ...... um-dependent activation of Raf
@nl
type
label
Ras-specific exchange factor G ...... um-dependent activation of Raf
@ast
Ras-specific exchange factor G ...... um-dependent activation of Raf
@en
Ras-specific exchange factor G ...... um-dependent activation of Raf
@nl
prefLabel
Ras-specific exchange factor G ...... um-dependent activation of Raf
@ast
Ras-specific exchange factor G ...... um-dependent activation of Raf
@en
Ras-specific exchange factor G ...... um-dependent activation of Raf
@nl
P2093
P2860
P356
P1476
Ras-specific exchange factor G ...... m-dependent activation of Raf.
@en
P2093
P2860
P304
P356
10.1128/MCB.19.7.4611
P407
P577
1999-07-01T00:00:00Z