Evidence for the existence of snRNAs U4 and U6 in a single ribonucleoprotein complex and for their association by intermolecular base pairing
about
The 20kD protein of human [U4/U6.U5] tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteinsAn evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2.The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicasesIdentification of an RNA-dependent ATPase activity in mammalian U5 snRNPsEvidence for a Prp24 binding site in U6 snRNA and in a putative intermediate in the annealing of U6 and U4 snRNAsU4 small nuclear RNA dissociates from a yeast spliceosome and does not participate in the subsequent splicing reactionStructural analyses of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown functionPRP28, a 'DEAD-box' protein, is required for the first step of mRNA splicing in vitroDirect cross-linking of snRNP proteins F and 70K to snRNAs by ultra-violet radiation in situU5 small nuclear ribonucleoprotein: RNA structure analysis and ATP-dependent interaction with U4/U6Structure of the K-turn U4 RNA: a combined NMR and SANS studyA U5 small nuclear ribonucleoprotein particle protein involved only in the second step of pre-mRNA splicing in Saccharomyces cerevisiae.The splicing factor PRP2, a putative RNA helicase, interacts directly with pre-mRNASpliceosome assembly involves the binding and release of U4 small nuclear ribonucleoproteinOrganization and transient expression of the gene for human U11 snRNA.Inhibition of U4 snRNA in human cells causes the stable retention of polyadenylated pre-mRNA in the nucleus.An abundant U6 snRNP found in germ cells and embryos of Xenopus laevis.Monospecific antibodies reveal details of U2 snRNP structure and interaction between U1 and U2 snRNPs.Purification of the individual snRNPs U1, U2, U5 and U4/U6 from HeLa cells and characterization of their protein constituentsSite-specific deoxynucleotide substitutions in yeast U6 snRNA block splicing of pre-mRNA in vitro.The U6 gene of Saccharomyces cerevisiae is transcribed by RNA polymerase C (III) in vivo and in vitro.Domains of U4 and U6 snRNAs required for snRNP assembly and splicing complementation in Xenopus oocytes.Formation of the 3' end of U1 snRNA is directed by a conserved sequence located downstream of the coding region.Deletion of a yeast small nuclear RNA gene impairs growth.Ribonucleoprotein multimers and their functions.Fractionation of HeLa cell nuclear extracts reveals minor small nuclear ribonucleoprotein particlesSpliceosome assembly in the absence of stable U4/U6 RNA pairing.RNA transport in dendrites: a cis-acting targeting element is contained within neuronal BC1 RNAA U6 snRNA gene with an internal promoter is juxtaposed to an snRNP protein sequence within an intron of a human G protein geneDevelopmental expression of plant snRNAsPurification of the major UsnRNPs from broad bean nuclear extracts and characterization of their protein constituents.Immunoprecipitation distinguishes non-overlapping groups of snRNPs in Schizosaccharomyces pombeSplicing of the U6 RNA precursor is impaired in fission yeast pre-mRNA splicing mutants.Pre-mRNA splicing by complementation with purified human U1, U2, U4/U6 and U5 snRNPsFunctional roles of protein splicing factors.Association of the lupus antigen La with a subset of U6 snRNA molecules.Ribonucleoprotein particles in cellular processes.Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors.U6 small nuclear RNA is transcribed by RNA polymerase IIIMutational analysis of Saccharomyces cerevisiae U4 small nuclear RNA identifies functionally important domains.
P2860
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P2860
Evidence for the existence of snRNAs U4 and U6 in a single ribonucleoprotein complex and for their association by intermolecular base pairing
description
1984 nî lūn-bûn
@nan
1984 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1984 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1984年の論文
@ja
1984年論文
@yue
1984年論文
@zh-hant
1984年論文
@zh-hk
1984年論文
@zh-mo
1984年論文
@zh-tw
1984年论文
@wuu
name
Evidence for the existence of ...... by intermolecular base pairing
@ast
Evidence for the existence of ...... by intermolecular base pairing
@en
Evidence for the existence of ...... by intermolecular base pairing
@nl
type
label
Evidence for the existence of ...... by intermolecular base pairing
@ast
Evidence for the existence of ...... by intermolecular base pairing
@en
Evidence for the existence of ...... by intermolecular base pairing
@nl
prefLabel
Evidence for the existence of ...... by intermolecular base pairing
@ast
Evidence for the existence of ...... by intermolecular base pairing
@en
Evidence for the existence of ...... by intermolecular base pairing
@nl
P2093
P2860
P1433
P1476
Evidence for the existence of ...... by intermolecular base pairing
@en
P2093
P2860
P304
P356
10.1002/J.1460-2075.1984.TB01977.X
P407
P577
1984-06-01T00:00:00Z