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Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein

Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein

http://www.wikidata.org/entity/Q28646807

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Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome Conservation of functional features of U6atac and U12 snRNAs between vertebrates and higher plants A mammalian protein of 220 kDa binds pre-mRNAs in the spliceosome: a potential homologue of the yeast PRP8 protein Evidence for a Prp24 binding site in U6 snRNA and in a putative intermediate in the annealing of U6 and U4 snRNAs U4 small nuclear RNA dissociates from a yeast spliceosome and does not participate in the subsequent splicing reaction A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction Structural analyses of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown function 20S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition PRP28, a 'DEAD-box' protein, is required for the first step of mRNA splicing in vitro Direct cross-linking of snRNP proteins F and 70K to snRNAs by ultra-violet radiation in situ Maple syrup urine disease caused by a partial deletion in the inner E2 core domain of the branched chain alpha-keto acid dehydrogenase complex due to aberrant splicing. A single base deletion at a 5'-splice donor site of an intron of the E2 gene dis U5 small nuclear ribonucleoprotein: RNA structure analysis and ATP-dependent interaction with U4/U6 Spliceosome activation by PRP2 ATPase prior to the first transesterification reaction of pre-mRNA splicing The yeast PRP6 gene encodes a U4/U6 small nuclear ribonucleoprotein particle (snRNP) protein, and the PRP9 gene encodes a protein required for U2 snRNP binding Cef1p is a component of the Prp19p-associated complex and essential for pre-mRNA splicing.Functional association of essential splicing factor(s) with PRP19 in a protein complex.Functional and physical interactions between components of the Prp19p-associated complex An abundant U6 snRNP found in germ cells and embryos of Xenopus laevis.PRP5: a helicase-like protein required for mRNA splicing in yeast Association of U2, U4, U5, and U6 small nuclear ribonucleoproteins in a spliceosome-type complex in absence of precursor RNA.Identification of a functional mammalian spliceosome containing unspliced pre-mRNA Electron microscopy of small nuclear ribonucleoprotein (snRNP) particles U2 and U5: evidence for a common structure-determining principle in the major U snRNP family Protein composition of mammalian spliceosomes assembled in vitro UACUAAC is the preferred branch site for mammalian mRNA splicing Site-specific deoxynucleotide substitutions in yeast U6 snRNA block splicing of pre-mRNA in vitro.Multiple domains of U1 snRNA, including U1 specific protein binding sites, are required for splicing.Domains of U4 and U6 snRNAs required for snRNP assembly and splicing complementation in Xenopus oocytes.Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.Genetic interactions of conserved regions in the DEAD-box protein Prp28p.The nuclear matrix phosphoprotein p255 associates with splicing complexes as part of the [U4/U6.U5] tri-snRNP particle.Purified U5 small nuclear ribonucleoprotein can relieve the inhibition of spliceosome assembly and splicing by snRNP-free nuclear proteins Spliceosome assembly in the absence of stable U4/U6 RNA pairing.Genetic depletion indicates a late role for U5 snRNP during in vitro spliceosome assembly.Interplay between U2 snRNP and 3' splice factor(s) for branch point selection on human beta-globin pre-mRNA Role of the branch site/3'-splice site region in adenovirus-2 E1A pre-mRNA alternative splicing: evidence for 5'- and 3'-splice site co-operation.Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.Splicing of the U6 RNA precursor is impaired in fission yeast pre-mRNA splicing mutants.

P2860

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P2860

Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein

http://www.wikidata.org/entity/Q28646807

description

1988 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

1988 թվականի հունվարին հրատարակված գիտական հոդված

@hy

article publié dans les Procee ...... f the United States of America

@fr

artículu científicu espublizáu en 1988

@ast

im Januar 1988 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 1988/01/01)

@sk

vědecký článek publikovaný v roce 1988

@cs

wetenschappelijk artikel (gepubliceerd op 1988/01/01)

@nl

наукова стаття, опублікована в січні 1988

@uk

name

Spliceosome assembly involves ...... mall nuclear ribonucleoprotein

@ast

Spliceosome assembly involves ...... mall nuclear ribonucleoprotein

@en

Spliceosome assembly involves ...... mall nuclear ribonucleoprotein

@nl

type

label

Spliceosome assembly involves ...... mall nuclear ribonucleoprotein

@ast

Spliceosome assembly involves ...... mall nuclear ribonucleoprotein

@en

Spliceosome assembly involves ...... mall nuclear ribonucleoprotein

@nl

prefLabel

Spliceosome assembly involves ...... mall nuclear ribonucleoprotein

@ast

Spliceosome assembly involves ...... mall nuclear ribonucleoprotein

@en

Spliceosome assembly involves ...... mall nuclear ribonucleoprotein

@nl

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P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Spliceosome assembly involves ...... mall nuclear ribonucleoprotein

@en

P2093

A. I. Lamond

http://www.w3.org/2001/XMLSchema#string

M. M. Konarska

http://www.w3.org/2001/XMLSchema#string

P. A. Sharp

http://www.w3.org/2001/XMLSchema#string

P. J. Grabowski

http://www.w3.org/2001/XMLSchema#string

P2860

Evidence for the existence of snRNAs U4 and U6 in a single ribonucleoprotein complex and for their association by intermolecular base pairing

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

Spliceosome assembly in yeast

U1, U2, and U4/U6 small nuclear ribonucleoproteins are required for in vitro splicing but not polyadenylation

Pre-mRNA splicing in vitro requires intact U4/U6 small nuclear ribonucleoprotein

An essential snRNA from S. cerevisiae has properties predicted for U4, including interaction with a U6-like snRNA

A compensatory base change in U1 snRNA suppresses a 5' splice site mutation

Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes

An ordered pathway of snRNP binding during mammalian pre-mRNA splicing complex assembly

U4 and U6 RNAs coexist in a single small nuclear ribonucleoprotein particle

P304

411–415

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P31

scholarly article

P356

10.1073/PNAS.85.2.411

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P407

P433

2

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P478

85

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P577

1988-01-01T00:00:00Z

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P5875

20193593

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P698

2963332

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P921

ribonucleoprotein

P932

279558

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